Varicella vaccination in children with nephrotic syndrome: A report of the southwest pediatric nephrology study group

Susan L. Furth, Gerald S. Arbus, Ronald Hogg, Joyce Tarver, Christina Chan, Barbara A. Fivush

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the safety and immunogenicity of varicella vaccine in children with nephrotic syndrome, including those taking low-dose, alternate-day prednisone. Study design: Prospective, open-label, multicenter clinical trial of varicella vaccine in a 2-dose regimen in US and Canadian children (12 months to <18 years) with nephrotic syndrome. Varicella Zoster Virus (VZV) antibody levels were measured after the first and second vaccine dose and yearly for 2 years. Patients were monitored for adverse reactions to vaccine, exposure to varicella, dermatomal zoster, and chickenpox. Results: Twenty-nine children, mean age 4.9 (SD 1.9) years, 45% receiving every-other-day steroids, received 2 vaccine doses. All patients seroconverted and had VZV antibody levels considered protective against breakthrough varicella (≥5 gpELISA units) after 2 doses. At 2-year follow-up, all patients retained detectable antibody, and 91% (21 of 23) had levels ≥5 gpELISA units. There were no adverse events associated with vaccination. Conclusions: Varicella vaccine was generally well tolerated and highly immunogenic in children with nephrotic syndrome, including those on low-dose, alternate-day prednisone.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalJournal of Pediatrics
Volume142
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Varicella vaccination in children with nephrotic syndrome: A report of the southwest pediatric nephrology study group'. Together they form a unique fingerprint.

  • Cite this