Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children

Jane Ellen Aronson, George McSherry, Laura Hoyt, Mary Boland, James Oleske, Edward Connor, Deborah Persaud, William Borkowsky, Keith Krasinski, Saroj Bakshi, Jane Pitt, Anne Gershon

Research output: Contribution to journalArticle

Abstract

We performed a retrospective analysis of longitudinal clinical and immunologic data obtained from 22 children in the early stages of infection with human immunodeficiency virus (HIV) when they developed varicella. We studied the course of HIV infection to determine whether clinical deterioration occurred after chickenpox. We examined the following indices: growth and development; neurologic status; helper T lymphocyte counts; blood values of core (p24) antigen of HIV; changesin the stage of HIV infection; and need for administration of zidovudine. We studied children for a mean of 2.8 years and for as long as 9.8 years after onset of varicella. There was little evidence that chickenpox affected HIV infection. Three (14%) children developed clinical zoster, 2 of whom (9%) had evidence of chronic infection with varicella-zoster virus. One additional child (5%) had 2 episodes of chickenpox. These observations suggest that children with early HIV infection could be considered for immunization with live attenuated varicella vaccine, which would be predicted to decrease their morbidity from varicella-zoster virus.

Original languageEnglish (US)
Pages (from-to)1004-1008
Number of pages5
JournalPediatric Infectious Disease Journal
Volume11
Issue number12
StatePublished - 1992
Externally publishedYes

Fingerprint

Chickenpox
Virus Diseases
HIV
Human Herpesvirus 3
Chickenpox Vaccine
Attenuated Vaccines
Zidovudine
Herpes Zoster
Lymphocyte Count
Helper-Inducer T-Lymphocytes
Infection
Growth and Development
Nervous System
Immunization
Morbidity
Antigens

Keywords

  • Acquired immunodeficiency syndrome
  • Human immunodeficiency virus infection
  • Varicella
  • Zoster

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health

Cite this

Aronson, J. E., McSherry, G., Hoyt, L., Boland, M., Oleske, J., Connor, E., ... Gershon, A. (1992). Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children. Pediatric Infectious Disease Journal, 11(12), 1004-1008.

Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children. / Aronson, Jane Ellen; McSherry, George; Hoyt, Laura; Boland, Mary; Oleske, James; Connor, Edward; Persaud, Deborah; Borkowsky, William; Krasinski, Keith; Bakshi, Saroj; Pitt, Jane; Gershon, Anne.

In: Pediatric Infectious Disease Journal, Vol. 11, No. 12, 1992, p. 1004-1008.

Research output: Contribution to journalArticle

Aronson, JE, McSherry, G, Hoyt, L, Boland, M, Oleske, J, Connor, E, Persaud, D, Borkowsky, W, Krasinski, K, Bakshi, S, Pitt, J & Gershon, A 1992, 'Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children', Pediatric Infectious Disease Journal, vol. 11, no. 12, pp. 1004-1008.
Aronson JE, McSherry G, Hoyt L, Boland M, Oleske J, Connor E et al. Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children. Pediatric Infectious Disease Journal. 1992;11(12):1004-1008.
Aronson, Jane Ellen ; McSherry, George ; Hoyt, Laura ; Boland, Mary ; Oleske, James ; Connor, Edward ; Persaud, Deborah ; Borkowsky, William ; Krasinski, Keith ; Bakshi, Saroj ; Pitt, Jane ; Gershon, Anne. / Varicella does not appear to be a cofactor for human immunodeficiency virus infection in children. In: Pediatric Infectious Disease Journal. 1992 ; Vol. 11, No. 12. pp. 1004-1008.
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