Variations in ocular biometry in an adult Chinese population in Singapore: The Tanjong Pagar survey

Yin Wong Tien Yin Wong, P. J. Foster, Pin Ng Tze Pin Ng, J. M. Tielsch, G. J. Johnson, S. K L Seah

Research output: Contribution to journalArticle

Abstract

PURPOSE. To describe the variation in ocular biometry in adult Chinese individuals in Singapore. METHODS. This study was a population-based, cross-sectional survey of adult Chinese persons aged 40 to 81 years residing in Tanjong Pagar district, Singapore. Axial ocular dimensions, including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and vitreous chamber depth (VCD) were measured using an A-scan ultrasound device. Corneal curvature (CC) and noncycloplegic refraction were measured with an autorefractor, with refraction further refined subjectively. Lens nuclear opacity (NO) was graded clinically using the modified Lens Opacity Classification System III (LOCS III) score. RESULTS. A total of 1717 subjects were eligible for the survey, of whom 1232 (71.8%) participated. Biometric and refraction data were available for 1004 (58.5%) phakic subjects. The AL, ACD, LT, VCD, CC, and LOCS III scores were 23.23 ± 1.17 mm, 2.90 ± 0.44 mm, 4.75 ± 0.47 mm, 15.58 ± 1.11 mm, 7.65 ± 0.27 mm, and 3.2 ± 0.9 (mean ± SD), respectively. On average, people aged 40 to 49 years, when compared with those 70 to 81 years, had longer ALs (mean difference, +0.58 mm), deeper ACDs (+0.52 mm), longer VCDs (+0.72 mm), but thinner lenses (- 0.70 mm) and less severe NO (- 1.7 LOCS III score). CCs did not vary significantly with age. After controlling for age, women had shorter ALs and VCDs, shallower ACDs, but thicker lenses and steeper CCs than men. The variation in noncycloplegic refraction with age was nonlinear. Among people aged 40 to 59 years, a higher prevalence of hyperopia was seen in older compared with younger persons (on average, a difference of + 1.3 D for every 10-year difference in age, P <0.001), explained principally by shorter AL (and VCD) in older persons. Among those 60 to 81 years, this pattern was not obvious (a difference of -0.03 D for every 10-year difference in age, P = 0.12), as NO became an additional determinant of refraction, with greater degrees of NO in older person's driving refraction in the "minus" direction. CONCLUSIONS. Ocular dimensions vary with age and gender in adult Chinese persons in Singapore. The variation in noncycloplegic refraction in people 40 years and older may be explained by differences in axial lengths (principally vitreous chamber depths) between older and younger persons and, from 60 years onwards, differences in lens nuclear opacification as well.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume42
Issue number1
StatePublished - 2001
Externally publishedYes

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Biometry
Singapore
Lenses
Cataract
Population
Anterior Chamber
Corneal Opacity
Surveys and Questionnaires
Cross-Sectional Studies
Equipment and Supplies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tien Yin Wong, Y. W., Foster, P. J., Tze Pin Ng, P. N., Tielsch, J. M., Johnson, G. J., & Seah, S. K. L. (2001). Variations in ocular biometry in an adult Chinese population in Singapore: The Tanjong Pagar survey. Investigative Ophthalmology and Visual Science, 42(1), 73-80.

Variations in ocular biometry in an adult Chinese population in Singapore : The Tanjong Pagar survey. / Tien Yin Wong, Yin Wong; Foster, P. J.; Tze Pin Ng, Pin Ng; Tielsch, J. M.; Johnson, G. J.; Seah, S. K L.

In: Investigative Ophthalmology and Visual Science, Vol. 42, No. 1, 2001, p. 73-80.

Research output: Contribution to journalArticle

Tien Yin Wong, YW, Foster, PJ, Tze Pin Ng, PN, Tielsch, JM, Johnson, GJ & Seah, SKL 2001, 'Variations in ocular biometry in an adult Chinese population in Singapore: The Tanjong Pagar survey', Investigative Ophthalmology and Visual Science, vol. 42, no. 1, pp. 73-80.
Tien Yin Wong YW, Foster PJ, Tze Pin Ng PN, Tielsch JM, Johnson GJ, Seah SKL. Variations in ocular biometry in an adult Chinese population in Singapore: The Tanjong Pagar survey. Investigative Ophthalmology and Visual Science. 2001;42(1):73-80.
Tien Yin Wong, Yin Wong ; Foster, P. J. ; Tze Pin Ng, Pin Ng ; Tielsch, J. M. ; Johnson, G. J. ; Seah, S. K L. / Variations in ocular biometry in an adult Chinese population in Singapore : The Tanjong Pagar survey. In: Investigative Ophthalmology and Visual Science. 2001 ; Vol. 42, No. 1. pp. 73-80.
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abstract = "PURPOSE. To describe the variation in ocular biometry in adult Chinese individuals in Singapore. METHODS. This study was a population-based, cross-sectional survey of adult Chinese persons aged 40 to 81 years residing in Tanjong Pagar district, Singapore. Axial ocular dimensions, including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and vitreous chamber depth (VCD) were measured using an A-scan ultrasound device. Corneal curvature (CC) and noncycloplegic refraction were measured with an autorefractor, with refraction further refined subjectively. Lens nuclear opacity (NO) was graded clinically using the modified Lens Opacity Classification System III (LOCS III) score. RESULTS. A total of 1717 subjects were eligible for the survey, of whom 1232 (71.8{\%}) participated. Biometric and refraction data were available for 1004 (58.5{\%}) phakic subjects. The AL, ACD, LT, VCD, CC, and LOCS III scores were 23.23 ± 1.17 mm, 2.90 ± 0.44 mm, 4.75 ± 0.47 mm, 15.58 ± 1.11 mm, 7.65 ± 0.27 mm, and 3.2 ± 0.9 (mean ± SD), respectively. On average, people aged 40 to 49 years, when compared with those 70 to 81 years, had longer ALs (mean difference, +0.58 mm), deeper ACDs (+0.52 mm), longer VCDs (+0.72 mm), but thinner lenses (- 0.70 mm) and less severe NO (- 1.7 LOCS III score). CCs did not vary significantly with age. After controlling for age, women had shorter ALs and VCDs, shallower ACDs, but thicker lenses and steeper CCs than men. The variation in noncycloplegic refraction with age was nonlinear. Among people aged 40 to 59 years, a higher prevalence of hyperopia was seen in older compared with younger persons (on average, a difference of + 1.3 D for every 10-year difference in age, P <0.001), explained principally by shorter AL (and VCD) in older persons. Among those 60 to 81 years, this pattern was not obvious (a difference of -0.03 D for every 10-year difference in age, P = 0.12), as NO became an additional determinant of refraction, with greater degrees of NO in older person's driving refraction in the {"}minus{"} direction. CONCLUSIONS. Ocular dimensions vary with age and gender in adult Chinese persons in Singapore. The variation in noncycloplegic refraction in people 40 years and older may be explained by differences in axial lengths (principally vitreous chamber depths) between older and younger persons and, from 60 years onwards, differences in lens nuclear opacification as well.",
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T1 - Variations in ocular biometry in an adult Chinese population in Singapore

T2 - The Tanjong Pagar survey

AU - Tien Yin Wong, Yin Wong

AU - Foster, P. J.

AU - Tze Pin Ng, Pin Ng

AU - Tielsch, J. M.

AU - Johnson, G. J.

AU - Seah, S. K L

PY - 2001

Y1 - 2001

N2 - PURPOSE. To describe the variation in ocular biometry in adult Chinese individuals in Singapore. METHODS. This study was a population-based, cross-sectional survey of adult Chinese persons aged 40 to 81 years residing in Tanjong Pagar district, Singapore. Axial ocular dimensions, including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and vitreous chamber depth (VCD) were measured using an A-scan ultrasound device. Corneal curvature (CC) and noncycloplegic refraction were measured with an autorefractor, with refraction further refined subjectively. Lens nuclear opacity (NO) was graded clinically using the modified Lens Opacity Classification System III (LOCS III) score. RESULTS. A total of 1717 subjects were eligible for the survey, of whom 1232 (71.8%) participated. Biometric and refraction data were available for 1004 (58.5%) phakic subjects. The AL, ACD, LT, VCD, CC, and LOCS III scores were 23.23 ± 1.17 mm, 2.90 ± 0.44 mm, 4.75 ± 0.47 mm, 15.58 ± 1.11 mm, 7.65 ± 0.27 mm, and 3.2 ± 0.9 (mean ± SD), respectively. On average, people aged 40 to 49 years, when compared with those 70 to 81 years, had longer ALs (mean difference, +0.58 mm), deeper ACDs (+0.52 mm), longer VCDs (+0.72 mm), but thinner lenses (- 0.70 mm) and less severe NO (- 1.7 LOCS III score). CCs did not vary significantly with age. After controlling for age, women had shorter ALs and VCDs, shallower ACDs, but thicker lenses and steeper CCs than men. The variation in noncycloplegic refraction with age was nonlinear. Among people aged 40 to 59 years, a higher prevalence of hyperopia was seen in older compared with younger persons (on average, a difference of + 1.3 D for every 10-year difference in age, P <0.001), explained principally by shorter AL (and VCD) in older persons. Among those 60 to 81 years, this pattern was not obvious (a difference of -0.03 D for every 10-year difference in age, P = 0.12), as NO became an additional determinant of refraction, with greater degrees of NO in older person's driving refraction in the "minus" direction. CONCLUSIONS. Ocular dimensions vary with age and gender in adult Chinese persons in Singapore. The variation in noncycloplegic refraction in people 40 years and older may be explained by differences in axial lengths (principally vitreous chamber depths) between older and younger persons and, from 60 years onwards, differences in lens nuclear opacification as well.

AB - PURPOSE. To describe the variation in ocular biometry in adult Chinese individuals in Singapore. METHODS. This study was a population-based, cross-sectional survey of adult Chinese persons aged 40 to 81 years residing in Tanjong Pagar district, Singapore. Axial ocular dimensions, including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and vitreous chamber depth (VCD) were measured using an A-scan ultrasound device. Corneal curvature (CC) and noncycloplegic refraction were measured with an autorefractor, with refraction further refined subjectively. Lens nuclear opacity (NO) was graded clinically using the modified Lens Opacity Classification System III (LOCS III) score. RESULTS. A total of 1717 subjects were eligible for the survey, of whom 1232 (71.8%) participated. Biometric and refraction data were available for 1004 (58.5%) phakic subjects. The AL, ACD, LT, VCD, CC, and LOCS III scores were 23.23 ± 1.17 mm, 2.90 ± 0.44 mm, 4.75 ± 0.47 mm, 15.58 ± 1.11 mm, 7.65 ± 0.27 mm, and 3.2 ± 0.9 (mean ± SD), respectively. On average, people aged 40 to 49 years, when compared with those 70 to 81 years, had longer ALs (mean difference, +0.58 mm), deeper ACDs (+0.52 mm), longer VCDs (+0.72 mm), but thinner lenses (- 0.70 mm) and less severe NO (- 1.7 LOCS III score). CCs did not vary significantly with age. After controlling for age, women had shorter ALs and VCDs, shallower ACDs, but thicker lenses and steeper CCs than men. The variation in noncycloplegic refraction with age was nonlinear. Among people aged 40 to 59 years, a higher prevalence of hyperopia was seen in older compared with younger persons (on average, a difference of + 1.3 D for every 10-year difference in age, P <0.001), explained principally by shorter AL (and VCD) in older persons. Among those 60 to 81 years, this pattern was not obvious (a difference of -0.03 D for every 10-year difference in age, P = 0.12), as NO became an additional determinant of refraction, with greater degrees of NO in older person's driving refraction in the "minus" direction. CONCLUSIONS. Ocular dimensions vary with age and gender in adult Chinese persons in Singapore. The variation in noncycloplegic refraction in people 40 years and older may be explained by differences in axial lengths (principally vitreous chamber depths) between older and younger persons and, from 60 years onwards, differences in lens nuclear opacification as well.

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