Variational intensity cross channel encoder for unsupervised vessel segmentation on OCT angiography

Yihao Liu, Lianrui Zuo, Aaron Carass, Yufan He, Angeliki Filippatou, Sharon D. Solomon, Shiv Saidha, Peter A. Calabresi, Jerry L. Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Deep learning approaches have been used extensively for medical image segmentation tasks. Training deep networks for segmentation, however, typically requires manually delineated examples which provide a ground truth for optimization of the network. In this work, we present a neural network architecture that segments vascular structures in retinal OCTA images without the need of direct supervision. Instead, we propose a variational intensity cross channel encoder that finds vessel masks by exploiting the common underlying structure shared by two OCTA images of the the same region but acquired on different devices. Experimental results demonstrate significant improvement over three existing methods that are commonly used.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2020
Subtitle of host publicationImage Processing
EditorsIvana Isgum, Bennett A. Landman
ISBN (Electronic)9781510633933
StatePublished - 2020
Externally publishedYes
EventMedical Imaging 2020: Image Processing - Houston, United States
Duration: Feb 17 2020Feb 20 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2020: Image Processing
Country/TerritoryUnited States


  • Image synthesis
  • OCTA
  • Unsupervised segmentation
  • Variational autoencoder
  • Vessel segmentation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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