Abstract
Micali et al. report that human telencephalic NSCs in vitro transition through the organizer states that pattern the neocortex. Human pluripotent lines vary in organizer formation, generating divergent neuronal differentiation trajectories biased toward dorsal or ventral telencephalic fates and opening further analysis of the earliest cortical specification events.
Original language | English (US) |
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Article number | 107599 |
Journal | Cell Reports |
Volume | 31 |
Issue number | 5 |
DOIs | |
State | Published - May 5 2020 |
Keywords
- BMP
- EGFR
- FGF2
- brain organizer
- glutamatergic neurons
- human iPSC variation
- inhibitory neurons
- neural stem cell
- neural transcriptional dynamics
- neurogenesis
- neuronal trajectory variation
- patterning of the cortex
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology