Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates

Nicola Micali, Suel Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O'Brien, Seungmae Seo, Joo Heon Shin, Brian G. Rash, Shaojie Ma, Yanhong Wang, Nicolas A. Olivares, Jon I. Arellano, Kristen R. Maynard, Elana J. Fertig, Alan J. Cross, Roland W. Bürli, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad SestanPasko Rakic, Carlo Colantuoni, Ronald D. McKay

Research output: Contribution to journalArticlepeer-review

Abstract

Micali et al. report that human telencephalic NSCs in vitro transition through the organizer states that pattern the neocortex. Human pluripotent lines vary in organizer formation, generating divergent neuronal differentiation trajectories biased toward dorsal or ventral telencephalic fates and opening further analysis of the earliest cortical specification events.

Original languageEnglish (US)
Article number107599
JournalCell Reports
Volume31
Issue number5
DOIs
StatePublished - May 5 2020

Keywords

  • BMP
  • EGFR
  • FGF2
  • brain organizer
  • glutamatergic neurons
  • human iPSC variation
  • inhibitory neurons
  • neural stem cell
  • neural transcriptional dynamics
  • neurogenesis
  • neuronal trajectory variation
  • patterning of the cortex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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