@article{fe9ab081d6354a49be4155371f1a5a9f,
title = "Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates",
abstract = "Micali et al. report that human telencephalic NSCs in vitro transition through the organizer states that pattern the neocortex. Human pluripotent lines vary in organizer formation, generating divergent neuronal differentiation trajectories biased toward dorsal or ventral telencephalic fates and opening further analysis of the earliest cortical specification events.",
keywords = "BMP, EGFR, FGF2, brain organizer, glutamatergic neurons, human iPSC variation, inhibitory neurons, neural stem cell, neural transcriptional dynamics, neurogenesis, neuronal trajectory variation, patterning of the cortex",
author = "Nicola Micali and Kim, {Suel Kee} and Marcelo Diaz-Bustamante and Genevieve Stein-O'Brien and Seungmae Seo and Shin, {Joo Heon} and Rash, {Brian G.} and Shaojie Ma and Yanhong Wang and Olivares, {Nicolas A.} and Arellano, {Jon I.} and Maynard, {Kristen R.} and Fertig, {Elana J.} and Cross, {Alan J.} and B{\"u}rli, {Roland W.} and Brandon, {Nicholas J.} and Weinberger, {Daniel R.} and Chenoweth, {Joshua G.} and Hoeppner, {Daniel J.} and Nenad Sestan and Pasko Rakic and Carlo Colantuoni and McKay, {Ronald D.}",
note = "Funding Information: This work was supported by the Lieber Institute for Brain Development (LIBD), AstraZeneca, and NIH grants DA02399 and EY002593 (to P.R.) and MH106934 , MH106874 , MH116488 , MH110926 , and MH109904 (to N.S.). E.J.F. and G.S.-O. were supported by the NIH ( CA177669 , CA212007 , and CA006973 ), the Johns Hopkins University Discovery Award , and the Johns Hopkins School of Medicine Synergy Award . We thank many members of LIBD and the Yale University Department of Neuroscience (Rakic and {\v S}estan labs) for their helpful comments on this work and manuscript. We thank Dr. Alvaro Duque (Rakic lab) and MacBrainResource ( https://medicine.yale.edu/neuroscience/macbrain/ ) for providing non-human primate (NHP) tissue ( National Institute of Mental Health (NIMH) R01-MH113257 to Alvaro Duque). ",
year = "2020",
month = may,
day = "5",
doi = "10.1016/j.celrep.2020.107599",
language = "English (US)",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}