Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style

Alessandro Bertolino, Giampiero Arciero, Valeria Rubino, Valeria Latorre, Mariapia De Candia, Viridiana Mazzola, Giuseppe Blasi, Grazia Caforio, Ahmad Hariri, Bhaskar Kolachana, Marcello Nardini, Daniel Weinberger, Tommaso Scarabino

Research output: Contribution to journalArticle

Abstract

Background: In the brain, processing of fearful stimuli engages the amygdala, and the variability of its activity is associated with genetic factors as well as with emotional salience. The objective of this study was to explore the relevance of personality style for variability of amygdala response. Methods: We studied two groups (n = 14 in each group) of healthy subjects categorized by contrasting cognitive styles with which they attribute salience to fearful stimuli: so-called phobic prone subjects who exaggerate potential environmental threat versus so-called eating disorders prone subjects who tend to be much less centered around fear. The two groups underwent functional magnetic resonance imaging (fMRI) at 3T during performance of a perceptual task of threatening stimuli and they were also matched for the genotype of the 5' variable number tandem repeat (VNTR) polymorphism in the serotonin transporter. Results: The fMRI results indicated that phobic prone subjects selectively recruit the amygdala to a larger extent than eating disorders prone subjects. Activity in the amygdala was also independently predicted by personality style and genotype of the serotonin transporter. Moreover, brain activity during a working memory task did not differentiate the two groups. Conclusions: The results of the present study suggest that aspects of personality style are rooted in biological responses of the fear circuitry associated with processing of environmental information.

Original languageEnglish (US)
Pages (from-to)1517-1525
Number of pages9
JournalBiological Psychiatry
Volume57
Issue number12
DOIs
StatePublished - Jun 15 2005
Externally publishedYes

Fingerprint

Amygdala
Personality
Genotype
Serotonin Plasma Membrane Transport Proteins
Fear
Magnetic Resonance Imaging
Minisatellite Repeats
Brain
Automatic Data Processing
Short-Term Memory
Healthy Volunteers
Feeding and Eating Disorders

Keywords

  • Amygdala
  • Fear
  • fMRI
  • Genetic factors
  • Personality style
  • Serotonin transporter genotype

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Bertolino, A., Arciero, G., Rubino, V., Latorre, V., De Candia, M., Mazzola, V., ... Scarabino, T. (2005). Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style. Biological Psychiatry, 57(12), 1517-1525. https://doi.org/10.1016/j.biopsych.2005.02.031

Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style. / Bertolino, Alessandro; Arciero, Giampiero; Rubino, Valeria; Latorre, Valeria; De Candia, Mariapia; Mazzola, Viridiana; Blasi, Giuseppe; Caforio, Grazia; Hariri, Ahmad; Kolachana, Bhaskar; Nardini, Marcello; Weinberger, Daniel; Scarabino, Tommaso.

In: Biological Psychiatry, Vol. 57, No. 12, 15.06.2005, p. 1517-1525.

Research output: Contribution to journalArticle

Bertolino, A, Arciero, G, Rubino, V, Latorre, V, De Candia, M, Mazzola, V, Blasi, G, Caforio, G, Hariri, A, Kolachana, B, Nardini, M, Weinberger, D & Scarabino, T 2005, 'Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style', Biological Psychiatry, vol. 57, no. 12, pp. 1517-1525. https://doi.org/10.1016/j.biopsych.2005.02.031
Bertolino, Alessandro ; Arciero, Giampiero ; Rubino, Valeria ; Latorre, Valeria ; De Candia, Mariapia ; Mazzola, Viridiana ; Blasi, Giuseppe ; Caforio, Grazia ; Hariri, Ahmad ; Kolachana, Bhaskar ; Nardini, Marcello ; Weinberger, Daniel ; Scarabino, Tommaso. / Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style. In: Biological Psychiatry. 2005 ; Vol. 57, No. 12. pp. 1517-1525.
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