Variation in the ciliary neurotrophic factor gene and muscle strength in older caucasian women

Dan Arking, Daniele Daniele Fallin, Linda P Fried, Tao Li, Brock A. Beamer, Qian Li Xue, Aravinda Chakravarti, Jeremy D Walston

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women. DESIGN: Cross-sectional analysis of baseline data from the Women's Health and Aging Studies I (1992) and II (1994), complementary population-based studies. SETTING: Twelve contiguous ZIP code areas in Baltimore, Maryland. PARTICIPANTS: Three hundred sixty-three Caucasian, community-dwelling women aged 70 to 79. MEASUREMENTS: Participants were genotyped at the CNTF locus for eight single nucleotide polymorphisms (SNPs), including the null allele rs1800169. The dependent variables were grip strength and the frailty syndrome, identified as presence of three or more of five frailty indicators (weakness, slowness, weight loss, low physical activity, exhaustion). In addition to genotypes, independent variables of body mass index (BMI) and osteoarthritis of the hands were included. RESULTS: Using multivariate linear regression, single SNP analysis identified five SNPs significantly associated with grip strength (P <.05), after adjusting for age, BMI, and osteoarthritis. Haplotype analysis was performed, and a single haplotype associated with grip strength was identified (P

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalJournal of the American Geriatrics Society
Volume54
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Ciliary Neurotrophic Factor
Muscle Strength
Hand Strength
Single Nucleotide Polymorphism
Osteoarthritis
Haplotypes
Body Mass Index
Genes
Independent Living
Baltimore
Women's Health
Weight Loss
Linear Models
Hand
Cross-Sectional Studies
Alleles
Genotype
Exercise
Population

Keywords

  • Ciliary neurotrophic factor
  • Frailty
  • Genetics
  • Muscle strength
  • Older women

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Variation in the ciliary neurotrophic factor gene and muscle strength in older caucasian women. / Arking, Dan; Fallin, Daniele Daniele; Fried, Linda P; Li, Tao; Beamer, Brock A.; Xue, Qian Li; Chakravarti, Aravinda; Walston, Jeremy D.

In: Journal of the American Geriatrics Society, Vol. 54, No. 5, 05.2006, p. 823-826.

Research output: Contribution to journalArticle

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