Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

Y. J. Rosenberg, B. D. White, S. F. Papermaster, P. Zack, P. B. Jarling, G. A. Eddy, D. S. Burke, M. G. Lewis

Research output: Contribution to journalArticle

Abstract

In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalJournal of medical primatology
Volume20
Issue number4
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.'. Together they form a unique fingerprint.

Cite this