Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

Y. J. Rosenberg; B. D. White; S. F. Papermaster; P. Zack; P. B. Jarling; G. A. Eddy; D. S. Burke; M. G. Lewis

Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

Y. J. Rosenberg, B. D. White, S. F. Papermaster, P. Zack, P. B. Jarling, G. A. Eddy, D. S. Burke, M. G. Lewis

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.

Original language	English (US)
Pages (from-to)	206-210
Number of pages	5
Journal	Journal of medical primatology
Volume	20
Issue number	4
State	Published - Jun 1991

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Cite this

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title = "Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.",

abstract = "In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and {"}activated{"} (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.",

author = "Rosenberg, {Y. J.} and White, {B. D.} and Papermaster, {S. F.} and P. Zack and Jarling, {P. B.} and Eddy, {G. A.} and Burke, {D. S.} and Lewis, {M. G.}",

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AU - Rosenberg, Y. J.

AU - White, B. D.

AU - Papermaster, S. F.

AU - Zack, P.

AU - Jarling, P. B.

AU - Eddy, G. A.

AU - Burke, D. S.

AU - Lewis, M. G.

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N2 - In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.

AB - In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.

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Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

Abstract

ASJC Scopus subject areas

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