Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

Y. J. Rosenberg, B. D. White, S. F. Papermaster, P. Zack, P. B. Jarling, G. A. Eddy, D. S. Burke, M. G. Lewis

Research output: Contribution to journalArticle

Abstract

In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalJournal of Medical Primatology
Volume20
Issue number4
StatePublished - Jun 1991
Externally publishedYes

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Macaca nemestrina
CD4-CD8 Ratio
Macaca fascicularis
Macaca
T-Lymphocyte Subsets
lymphocyte proliferation
Lymphocyte Activation
Swine
T-lymphocytes
death
T-Lymphocytes
mononuclear leukocytes
virus replication
Infection
swine
infection
cells

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Rosenberg, Y. J., White, B. D., Papermaster, S. F., Zack, P., Jarling, P. B., Eddy, G. A., ... Lewis, M. G. (1991). Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques. Journal of Medical Primatology, 20(4), 206-210.

Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques. / Rosenberg, Y. J.; White, B. D.; Papermaster, S. F.; Zack, P.; Jarling, P. B.; Eddy, G. A.; Burke, D. S.; Lewis, M. G.

In: Journal of Medical Primatology, Vol. 20, No. 4, 06.1991, p. 206-210.

Research output: Contribution to journalArticle

Rosenberg, YJ, White, BD, Papermaster, SF, Zack, P, Jarling, PB, Eddy, GA, Burke, DS & Lewis, MG 1991, 'Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.', Journal of Medical Primatology, vol. 20, no. 4, pp. 206-210.
Rosenberg YJ, White BD, Papermaster SF, Zack P, Jarling PB, Eddy GA et al. Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques. Journal of Medical Primatology. 1991 Jun;20(4):206-210.
Rosenberg, Y. J. ; White, B. D. ; Papermaster, S. F. ; Zack, P. ; Jarling, P. B. ; Eddy, G. A. ; Burke, D. S. ; Lewis, M. G. / Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques. In: Journal of Medical Primatology. 1991 ; Vol. 20, No. 4. pp. 206-210.
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