Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related to Nppa and Npr1 gene knock-out mice

Clarke G. Tankersley, Roger Peng, Djahida Bedga, Kathleen L Gabrielson, Hunter C. Champion

Research output: Contribution to journalArticle

Abstract

Elevated levels of ambient co-pollutants are associated with adverse cardiovascular outcomes shown by epidemiology studies. The role of particulate matter (PM) and ozone (O3) as co-pollutants in this association is unclear. We hypothesize that cardiac function following PM and O3 exposure is variably affected by genetic determinants (Nppa and Npr1 genes) and age. Heart function was measured before and after 2 days each of the following exposure sequence; (1) 2-h filtered air (FA) and 3-h carbon black (CB; 0.5 g/m3); (2) 2-h O3 (0.6ppm) and 3-h FA; (3) 5-h FA; and, (4) 2-h O3 and 3-h CB. Two age groups (5 and 18 months old (mo)) were tested in C57Bl/6J (B6) and 129S1/SvImJ (129) mice using echocardiographic (echo) and in vivo hemodynamic (IVH) measurements. With echo, posterior wall thickness was significantly (P

Original languageEnglish (US)
Pages (from-to)695-707
Number of pages13
JournalInhalation Toxicology
Volume22
Issue number8
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Inhalation Exposure
Gene Knockout Techniques
Particulate Matter
Ozone
Hemodynamics
Knockout Mice
Genes
Air
129 Strain Mouse
Soot
Epidemiology
Age Groups

Keywords

  • Air pollution
  • Atrial natriuretic peptide
  • Cardiac structure and function
  • Cardiopulmonary regulation
  • Myocardial contractility

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related to Nppa and Npr1 gene knock-out mice. / Tankersley, Clarke G.; Peng, Roger; Bedga, Djahida; Gabrielson, Kathleen L; Champion, Hunter C.

In: Inhalation Toxicology, Vol. 22, No. 8, 2010, p. 695-707.

Research output: Contribution to journalArticle

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