Variation in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia

B. Hottor, P. Bosio, J. Waugh, P. J. Diggle, S. Byrne, J. Ahenkorah, C. D. Ockleford

Research output: Contribution to journalArticle

Abstract

Objective(s): To define composition of chorionic plate and test effects of pre-eclampsia on basal plate composition. Study Design: Retrospective cohort study where distinct area fractions were measured in: healthy term chorionic plate (CP: n = 11), healthy placental basal plate (n = 11), mild pre-eclamptic basal plate (n = 10) and severe pre-eclamptic basal plate (n = 11). Results: CP lining is partly endothelial. Mean anchoring villus (AV)/acellular (NS) basal plate area ratio decreased in pre-eclampsia (p = 0.048). There was a decreasing trend with increasing disease severity. Basal plate endothelial cell proportion was not significantly lower in severe pre-eclampsia than in healthy or mild pre-eclamptics. Conclusion(s): An inverse relationship between the proportions of fibrin and anchoring villi indicates that increased basal plate fibrin deposition and reduced basal plate materno-fetal anchoring area are part of pre-eclamptic disease progression. Endothelium lining intervillous surfaces may originate from circulating maternal endothelial progenitor cells.

Original languageEnglish (US)
Pages (from-to)409-417
Number of pages9
JournalPlacenta
Volume31
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Pre-Eclampsia
Placenta
Fibrin
Endothelium
Disease Progression
Cohort Studies
Endothelial Cells
Retrospective Studies
Mothers

Keywords

  • Anchoring villus
  • Basal plate
  • Endothelium
  • Fibrinoid lining
  • Intervillous space
  • Mosaic monolayer
  • Pre-eclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology

Cite this

Hottor, B., Bosio, P., Waugh, J., Diggle, P. J., Byrne, S., Ahenkorah, J., & Ockleford, C. D. (2010). Variation in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia. Placenta, 31(5), 409-417. https://doi.org/10.1016/j.placenta.2010.02.016

Variation in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia. / Hottor, B.; Bosio, P.; Waugh, J.; Diggle, P. J.; Byrne, S.; Ahenkorah, J.; Ockleford, C. D.

In: Placenta, Vol. 31, No. 5, 05.2010, p. 409-417.

Research output: Contribution to journalArticle

Hottor, B, Bosio, P, Waugh, J, Diggle, PJ, Byrne, S, Ahenkorah, J & Ockleford, CD 2010, 'Variation in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia', Placenta, vol. 31, no. 5, pp. 409-417. https://doi.org/10.1016/j.placenta.2010.02.016
Hottor, B. ; Bosio, P. ; Waugh, J. ; Diggle, P. J. ; Byrne, S. ; Ahenkorah, J. ; Ockleford, C. D. / Variation in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia. In: Placenta. 2010 ; Vol. 31, No. 5. pp. 409-417.
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