@article{87739ca4804f424aae7f00a087c66643,
title = "Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk",
abstract = "Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10 -11), irrespective of cell lineage.",
author = "Sherborne, {Amy L.} and Hosking, {Fay J.} and Prasad, {Rashmi B.} and Rajiv Kumar and Rolf Koehler and Jayaram Vijayakrishnan and Elli Papaemmanuil and Bartram, {Claus R.} and Martin Stanulla and Martin Schrappe and Andreas Gast and Dobbins, {Sara E.} and Yussanne Ma and Eamonn Sheridan and Malcolm Taylor and Kinsey, {Sally E.} and Tracey Lightfoot and Eve Roman and Irving, {Julie A.E.} and Allan, {James M.} and Moorman, {Anthony V.} and Harrison, {Christine J.} and Tomlinson, {Ian P.} and Sue Richards and Martin Zimmermann and Csaba Szalai and Semsei, {{\AA}gnes F.} and Erdelyi, {Daniel J.} and Maja Krajinovic and Daniel Sinnett and Jasmine Healy and Neira, {Anna Gonzalez} and Norihiko Kawamata and Seishi Ogawa and Koeffler, {H. Phillip} and Kari Hemminki and Mel Greaves and Houlston, {Richard S.}",
note = "Funding Information: The Kay Kendall Leukemia Fund and Leukemia Research (UK) provided principal funding for the study. Support from Cancer Research UK (C1298/A8362, supported by the Bobby Moore Fund) is also acknowledged. The study made use of genotyping data from the 1958 Birth Cohort which was generated and generously supplied to us by Panagiotis Deloukas of the Wellcome Trust Sanger Institute. For a full list of the investigators who contributed to the generation of the 1958 data, see URL section. We are grateful to S. Richards and J. Burrett (Clinical Trials Service Unit, Oxford) and L. Chilton (Leukaemia Research Cytogenetics Group, Northern Institute of Cancer Research, Newcastle Univ.), J. Simpson (Univ. York), P. Thomson and A. Hussain (Cancer Immunogenetics, School of Cancer Sciences, Univ. Manchester) for assistance with data harmonization. We thank the Leukaemia Research (LR) Childhood Cancer Leukaemia Group (CCLG) Childhood Leukaemia Cell Bank for access to the Medical Research Council ALL trial samples. We are grateful to the UK Cancer Cytogenetics Group (UKCCG) for data collection and provision of samples. P. Thomson (Cancer Immunogenetics, School of Cancer Sciences, University of Manchester) is funded by Children with Leukemia and we acknowledge their support. Genotyping of German cases and controls was partly covered by funding from Tumorzentrum Heidelberg-Mannheim, EU (Food-CT-2005-016320 and Health-F3-2007-2007-200767) and Deutsche Krebshilfe. The Hungarian sample collection was financially supported by grants from the Hungarian Scientific Research Fund (T042500), the Economic Competitiveness Operational Programme, Hungary (GVOP 3.1.1-2004-05-0022/3.0) and NKTH (National Research and Technology) TECH_08-A1/2-2008-0120. M.K. is a scholar of the Fonds de la Recherche en Sant{\'e} du Qu{\'e}bec. D.S. holds the Fran{\c c}ois-Karl Viau Chair in Pediatric Oncogenomics and is also a scholar of the Fonds de la Recherche en Sant{\'e} du Qu{\'e}bec. J.H. is the recipient of a National Sciences and Engineering Research Council Canada Graduate{\textquoteright}s scholarship. P. Garcia-Miguel and A. Sastre from Hospital Infantil La Paz, Madrid, and J. Luis Vivanco Mart{\'i}nez from Hospital 12 de Octubre, Madrid, were involved in the sample collection of the Spanish samples, and R. Alonso from Centro Nacional de Investigaciones Oncol{\'o}gicas was involved in the genotyping. We are grateful to all the study subjects and individuals for their participation and, finally, we would also like to thank the clinicians, other hospital staff and study staff who contributed to the blood sample and data collection for this study.",
year = "2010",
month = jun,
doi = "10.1038/ng.585",
language = "English (US)",
volume = "42",
pages = "492--494",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",
}