Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Amy L. Sherborne, Fay J. Hosking, Rashmi B. Prasad, Rajiv Kumar, Rolf Koehler, Jayaram Vijayakrishnan, Elli Papaemmanuil, Claus R. Bartram, Martin Stanulla, Martin Schrappe, Andreas Gast, Sara E. Dobbins, Yussanne Ma, Eamonn Sheridan, Malcolm Taylor, Sally E. Kinsey, Tracey Lightfoot, Eve Roman, Julie A.E. Irving, James M. AllanAnthony V. Moorman, Christine J. Harrison, Ian P. Tomlinson, Sue Richards, Martin Zimmermann, Csaba Szalai, Ågnes F. Semsei, Daniel J. Erdelyi, Maja Krajinovic, Daniel Sinnett, Jasmine Healy, Anna Gonzalez Neira, Norihiko Kawamata, Seishi Ogawa, H. Phillip Koeffler, Kari Hemminki, Mel Greaves, Richard S. Houlston

Research output: Contribution to journalArticlepeer-review

Abstract

Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10 -11), irrespective of cell lineage.

Original languageEnglish (US)
Pages (from-to)492-494
Number of pages3
JournalNature genetics
Volume42
Issue number6
DOIs
StatePublished - Jun 2010
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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