TY - JOUR
T1 - Variation in catechol-O-methyltransferase val 158 met genotype associated with schizotypy but not cognition
T2 - A population study in 543 young men
AU - Stefanis, Nicholas C.
AU - Os, Jim Van
AU - Avramopoulos, Dimitrios
AU - Smyrnis, Nikolaos
AU - Evdokimidis, Ioannis
AU - Hantoumi, Ioanna
AU - Stefanis, Costas N.
N1 - Funding Information:
This work was supported by the Grant EKBAN 97 (CNS) from the General Secretariat of Research and Technology of the Greek Ministry of Development. The technical support for this project was provided by Intrasoft Co. We thank the following colleagues, in alphabetical order, who helped in data acquisition and preprocessing: Ioannis Giouzelis, Georgios Kastrinakis, Emanouil Kattoulas, Catherine Paximadis, and Christos Theleritis.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Increased catechol-O-methyltransferase activity associated with variation in catechol-O-methyltransferase valine 158 methionine genotypesmay result in reduced dopamine neurotransmission in the prefrontal cortex and thus contribute to the poor performance of frontally mediated cognitive tasks and the occurrence of associated negative symptoms observed in patients with schizophrenia; however, reported associations between catechol-O- methyltransferase valine 158 methionine genotypes and measures of cognition have not been consistent. Catechol-O-methyltransferase genotyping, measures of schizotypy, cognitive measures of memory and attention, as well as the antisaccade eye movement task, a measure sensitive to prefrontal cortical function, were obtained in a sample of 543 young men representative for that age group (mean age 21 years). None of the cognitive measures was associated with catechol-O-methyltransferase valine 158 methionine genotypes; however, there was an effect of high-activity allele loading on schizotypy, in particular the negative and disorganization dimensions. Previously reported inconsistencies in the relationship between catechol-O-methyltransferase valine 158 methionine genotypes and cognition were not resolved; however, catechol-O-methyltransferase genotype may affect expression of negative schizotypy by direct or indirect effects on central dopamine neurotransmitter signaling.
AB - Increased catechol-O-methyltransferase activity associated with variation in catechol-O-methyltransferase valine 158 methionine genotypesmay result in reduced dopamine neurotransmission in the prefrontal cortex and thus contribute to the poor performance of frontally mediated cognitive tasks and the occurrence of associated negative symptoms observed in patients with schizophrenia; however, reported associations between catechol-O- methyltransferase valine 158 methionine genotypes and measures of cognition have not been consistent. Catechol-O-methyltransferase genotyping, measures of schizotypy, cognitive measures of memory and attention, as well as the antisaccade eye movement task, a measure sensitive to prefrontal cortical function, were obtained in a sample of 543 young men representative for that age group (mean age 21 years). None of the cognitive measures was associated with catechol-O-methyltransferase valine 158 methionine genotypes; however, there was an effect of high-activity allele loading on schizotypy, in particular the negative and disorganization dimensions. Previously reported inconsistencies in the relationship between catechol-O-methyltransferase valine 158 methionine genotypes and cognition were not resolved; however, catechol-O-methyltransferase genotype may affect expression of negative schizotypy by direct or indirect effects on central dopamine neurotransmitter signaling.
KW - Catechol-O-methyltransferase
KW - cognition
KW - genetics
KW - negative symptoms
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=4644362935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644362935&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2004.06.038
DO - 10.1016/j.biopsych.2004.06.038
M3 - Article
C2 - 15450787
AN - SCOPUS:4644362935
SN - 0006-3223
VL - 56
SP - 510
EP - 515
JO - Biological psychiatry
JF - Biological psychiatry
IS - 7
ER -