Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus

Amitabh Chak, Yanwen Chen, Jaime Vengoechea, Marcia Canto, Robert Elston, Gary W. Falk, William M. Grady, Kishore Guda, Margaret Kinnard, Sanford Markowitz, Sumeet Mittal, Ganapathy Prasad, Nicholas Shaheen, Joseph E. Willis, Jill S. Barnholtz-Sloan

Research output: Contribution to journalArticle

Abstract

Background: Genetic influences may be discerned in families that have multiple affected members and may manifest as an earlier age of cancer diagnosis. In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC). Methods: Information on BE/EAC risk factors and family history was collected from probands at eight tertiary care academic hospitals. Age of cancer diagnosis and other risk factors were compared between nonfamilial (no affected relatives), duplex (two affected relatives), and multiplex (three or more affected relatives) FBE kindreds. Results: The study included 830 nonfamilial, 274 duplex, and 41 multiplex FBE kindreds with 274, 133, and 43 EAC and 566, 288, and 103 BE cases, respectively. Multivariable mixed models adjusting for familial correlations showed that multiplex kindreds were associated with a younger age of cancer diagnosis (P = 0.0186). Median age of cancer diagnosis was significantly younger in multiplex compared with duplex and nonfamilial kindreds (57 vs. 62 vs. 63 years, respectively, P = 0.0448). Mean body mass index was significantly lower in multiplex kindreds (P = 0.0033), as was smoking (P <0.0001), and reported regurgitation (P = 0.0014). Conclusions: Members of multiplex FBE kindreds develop EA Cat an earlier age compared with nonfamilial EAC cases. Multiplex kindreds do not have a higher proportion of common risk factors for EAC, suggesting that this aggregation might be related to a genetic factor. Impact: These findings indicate that efforts to identify susceptibility genes for BE and EAC will need to focus on multiplex kindreds.

Original languageEnglish (US)
Pages (from-to)376-383
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number2
DOIs
StatePublished - Feb 2012

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Barrett Esophagus
Adenocarcinoma
Neoplasms
Tertiary Healthcare
Early Detection of Cancer
Cats
Body Mass Index
Smoking

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus. / Chak, Amitabh; Chen, Yanwen; Vengoechea, Jaime; Canto, Marcia; Elston, Robert; Falk, Gary W.; Grady, William M.; Guda, Kishore; Kinnard, Margaret; Markowitz, Sanford; Mittal, Sumeet; Prasad, Ganapathy; Shaheen, Nicholas; Willis, Joseph E.; Barnholtz-Sloan, Jill S.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 2, 02.2012, p. 376-383.

Research output: Contribution to journalArticle

Chak, A, Chen, Y, Vengoechea, J, Canto, M, Elston, R, Falk, GW, Grady, WM, Guda, K, Kinnard, M, Markowitz, S, Mittal, S, Prasad, G, Shaheen, N, Willis, JE & Barnholtz-Sloan, JS 2012, 'Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 2, pp. 376-383. https://doi.org/10.1158/1055-9965.EPI-11-0927
Chak, Amitabh ; Chen, Yanwen ; Vengoechea, Jaime ; Canto, Marcia ; Elston, Robert ; Falk, Gary W. ; Grady, William M. ; Guda, Kishore ; Kinnard, Margaret ; Markowitz, Sanford ; Mittal, Sumeet ; Prasad, Ganapathy ; Shaheen, Nicholas ; Willis, Joseph E. ; Barnholtz-Sloan, Jill S. / Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 2. pp. 376-383.
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abstract = "Background: Genetic influences may be discerned in families that have multiple affected members and may manifest as an earlier age of cancer diagnosis. In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC). Methods: Information on BE/EAC risk factors and family history was collected from probands at eight tertiary care academic hospitals. Age of cancer diagnosis and other risk factors were compared between nonfamilial (no affected relatives), duplex (two affected relatives), and multiplex (three or more affected relatives) FBE kindreds. Results: The study included 830 nonfamilial, 274 duplex, and 41 multiplex FBE kindreds with 274, 133, and 43 EAC and 566, 288, and 103 BE cases, respectively. Multivariable mixed models adjusting for familial correlations showed that multiplex kindreds were associated with a younger age of cancer diagnosis (P = 0.0186). Median age of cancer diagnosis was significantly younger in multiplex compared with duplex and nonfamilial kindreds (57 vs. 62 vs. 63 years, respectively, P = 0.0448). Mean body mass index was significantly lower in multiplex kindreds (P = 0.0033), as was smoking (P <0.0001), and reported regurgitation (P = 0.0014). Conclusions: Members of multiplex FBE kindreds develop EA Cat an earlier age compared with nonfamilial EAC cases. Multiplex kindreds do not have a higher proportion of common risk factors for EAC, suggesting that this aggregation might be related to a genetic factor. Impact: These findings indicate that efforts to identify susceptibility genes for BE and EAC will need to focus on multiplex kindreds.",
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T1 - Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus

AU - Chak, Amitabh

AU - Chen, Yanwen

AU - Vengoechea, Jaime

AU - Canto, Marcia

AU - Elston, Robert

AU - Falk, Gary W.

AU - Grady, William M.

AU - Guda, Kishore

AU - Kinnard, Margaret

AU - Markowitz, Sanford

AU - Mittal, Sumeet

AU - Prasad, Ganapathy

AU - Shaheen, Nicholas

AU - Willis, Joseph E.

AU - Barnholtz-Sloan, Jill S.

PY - 2012/2

Y1 - 2012/2

N2 - Background: Genetic influences may be discerned in families that have multiple affected members and may manifest as an earlier age of cancer diagnosis. In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC). Methods: Information on BE/EAC risk factors and family history was collected from probands at eight tertiary care academic hospitals. Age of cancer diagnosis and other risk factors were compared between nonfamilial (no affected relatives), duplex (two affected relatives), and multiplex (three or more affected relatives) FBE kindreds. Results: The study included 830 nonfamilial, 274 duplex, and 41 multiplex FBE kindreds with 274, 133, and 43 EAC and 566, 288, and 103 BE cases, respectively. Multivariable mixed models adjusting for familial correlations showed that multiplex kindreds were associated with a younger age of cancer diagnosis (P = 0.0186). Median age of cancer diagnosis was significantly younger in multiplex compared with duplex and nonfamilial kindreds (57 vs. 62 vs. 63 years, respectively, P = 0.0448). Mean body mass index was significantly lower in multiplex kindreds (P = 0.0033), as was smoking (P <0.0001), and reported regurgitation (P = 0.0014). Conclusions: Members of multiplex FBE kindreds develop EA Cat an earlier age compared with nonfamilial EAC cases. Multiplex kindreds do not have a higher proportion of common risk factors for EAC, suggesting that this aggregation might be related to a genetic factor. Impact: These findings indicate that efforts to identify susceptibility genes for BE and EAC will need to focus on multiplex kindreds.

AB - Background: Genetic influences may be discerned in families that have multiple affected members and may manifest as an earlier age of cancer diagnosis. In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC). Methods: Information on BE/EAC risk factors and family history was collected from probands at eight tertiary care academic hospitals. Age of cancer diagnosis and other risk factors were compared between nonfamilial (no affected relatives), duplex (two affected relatives), and multiplex (three or more affected relatives) FBE kindreds. Results: The study included 830 nonfamilial, 274 duplex, and 41 multiplex FBE kindreds with 274, 133, and 43 EAC and 566, 288, and 103 BE cases, respectively. Multivariable mixed models adjusting for familial correlations showed that multiplex kindreds were associated with a younger age of cancer diagnosis (P = 0.0186). Median age of cancer diagnosis was significantly younger in multiplex compared with duplex and nonfamilial kindreds (57 vs. 62 vs. 63 years, respectively, P = 0.0448). Mean body mass index was significantly lower in multiplex kindreds (P = 0.0033), as was smoking (P <0.0001), and reported regurgitation (P = 0.0014). Conclusions: Members of multiplex FBE kindreds develop EA Cat an earlier age compared with nonfamilial EAC cases. Multiplex kindreds do not have a higher proportion of common risk factors for EAC, suggesting that this aggregation might be related to a genetic factor. Impact: These findings indicate that efforts to identify susceptibility genes for BE and EAC will need to focus on multiplex kindreds.

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