TY - JOUR
T1 - Variants of NOS1, NOS2, and NOS3 genes in asthmatics
AU - Gao, P. S.
AU - Kawada, H.
AU - Kasamatsu, T.
AU - Mao, X. Q.
AU - Roberts, M. H.
AU - Miyamoto, Y.
AU - Yoshimura, M.
AU - Saitoh, Y.
AU - Yasue, H.
AU - Nakao, K.
AU - Adra, C. N.
AU - Kun, J. F.
AU - Moro-Oka, S.
AU - Inoko, H.
AU - Ho, L. P.
AU - Shirakawa, T.
AU - Hopkin, J. M.
N1 - Funding Information:
This study was supported in part by a Wellcome Trust Collaborative Grant, a Grant-in-Aid from the Japanese Ministry of Science, Culture, and Education, and Research Grants from Ombas Co. (Tokyo, Japan) and Sakai Chemical Co. (Sakai, Japan).
PY - 2000/1/27
Y1 - 2000/1/27
N2 - Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI: 1.20-3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels. Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population. (C) 2000 Academic Press.
AB - Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI: 1.20-3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels. Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population. (C) 2000 Academic Press.
UR - http://www.scopus.com/inward/record.url?scp=0034719330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034719330&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1999.2030
DO - 10.1006/bbrc.1999.2030
M3 - Article
C2 - 10673365
AN - SCOPUS:0034719330
SN - 0006-291X
VL - 267
SP - 761
EP - 763
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -