Variants of NOS1, NOS2, and NOS3 genes in asthmatics

P. S. Gao, H. Kawada, T. Kasamatsu, X. Q. Mao, M. H. Roberts, Y. Miyamoto, M. Yoshimura, Y. Saitoh, H. Yasue, K. Nakao, C. N. Adra, J. F. Kun, S. Moro-Oka, H. Inoko, L. P. Ho, T. Shirakawa, J. M. Hopkin

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI: 1.20-3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels. Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)761-763
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume267
Issue number3
DOIs
StatePublished - Jan 27 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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