Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans

Genevieve Wojcik, Rachel Latanich, Tim Mosbruger, Jacquie Astemborski, Gregory D. Kirk, Shruti H. Mehta, James J. Goedert, Arthur Y. Kim, Eric C. Seaberg, Michael Busch, David L. Thomas, Priya Duggal, Chloe L. Thio

Research output: Contribution to journalArticlepeer-review

Abstract

To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P =. 01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10-4), as was one 81-kb haplotype (adjusted P =. 0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.

Original languageEnglish (US)
Pages (from-to)355-359
Number of pages5
JournalJournal of Infectious Diseases
Volume209
Issue number3
DOIs
StatePublished - Jan 24 2014

Keywords

  • Tim 1
  • hepatitis C virus
  • human genetics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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