Variants in FAM13A are associated with chronic obstructive pulmonary disease

Michael H. Cho, Nadia Boutaoui, Barbara J. Klanderman, Jody S. Sylvia, John P. Ziniti, Craig P. Hersh, Dawn L. Demeo, Gary M. Hunninghake, Augusto A. Litonjua, David Sparrow, Christoph Lange, Sungho Won, James R. Murphy, Terri H. Beaty, Elizabeth A. Regan, Barry J. Make, John E. Hokanson, James D. Crapo, Xiangyang Kong, Wayne H. AndersonRuth Tal-Singer, David A. Lomas, Per Bakke, Amund Gulsvik, Sreekumar G. Pillai, E. K. Silverman

Research output: Contribution to journalArticle

Abstract

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 × 10 11, combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).

Original languageEnglish (US)
Pages (from-to)200-202
Number of pages3
JournalNature genetics
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Cho, M. H., Boutaoui, N., Klanderman, B. J., Sylvia, J. S., Ziniti, J. P., Hersh, C. P., Demeo, D. L., Hunninghake, G. M., Litonjua, A. A., Sparrow, D., Lange, C., Won, S., Murphy, J. R., Beaty, T. H., Regan, E. A., Make, B. J., Hokanson, J. E., Crapo, J. D., Kong, X., ... Silverman, E. K. (2010). Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nature genetics, 42(3), 200-202. https://doi.org/10.1038/ng.535