Variants in FAM13A are associated with chronic obstructive pulmonary disease

Michael H. Cho, Nadia Boutaoui, Barbara J. Klanderman, Jody S. Sylvia, John P. Ziniti, Craig P. Hersh, Dawn L. Demeo, Gary M. Hunninghake, Augusto A. Litonjua, David Sparrow, Christoph Lange, Sungho Won, James R. Murphy, Terri L Beaty, Elizabeth A. Regan, Barry J. Make, John E. Hokanson, James D. Crapo, Xiangyang Kong, Wayne H. Anderson & 6 others Ruth Tal-Singer, David A. Lomas, Per Bakke, Amund Gulsvik, Sreekumar G. Pillai, E. K. Silverman

Research output: Contribution to journalArticle

Abstract

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 × 10 11, combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).

Original languageEnglish (US)
Pages (from-to)200-202
Number of pages3
JournalNature Genetics
Volume42
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

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Genome-Wide Association Study
Chronic Obstructive Pulmonary Disease
Case-Control Studies
Odds Ratio
Confidence Intervals
Lung
Control Groups
Population

ASJC Scopus subject areas

  • Genetics

Cite this

Cho, M. H., Boutaoui, N., Klanderman, B. J., Sylvia, J. S., Ziniti, J. P., Hersh, C. P., ... Silverman, E. K. (2010). Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nature Genetics, 42(3), 200-202. https://doi.org/10.1038/ng.535

Variants in FAM13A are associated with chronic obstructive pulmonary disease. / Cho, Michael H.; Boutaoui, Nadia; Klanderman, Barbara J.; Sylvia, Jody S.; Ziniti, John P.; Hersh, Craig P.; Demeo, Dawn L.; Hunninghake, Gary M.; Litonjua, Augusto A.; Sparrow, David; Lange, Christoph; Won, Sungho; Murphy, James R.; Beaty, Terri L; Regan, Elizabeth A.; Make, Barry J.; Hokanson, John E.; Crapo, James D.; Kong, Xiangyang; Anderson, Wayne H.; Tal-Singer, Ruth; Lomas, David A.; Bakke, Per; Gulsvik, Amund; Pillai, Sreekumar G.; Silverman, E. K.

In: Nature Genetics, Vol. 42, No. 3, 03.2010, p. 200-202.

Research output: Contribution to journalArticle

Cho, MH, Boutaoui, N, Klanderman, BJ, Sylvia, JS, Ziniti, JP, Hersh, CP, Demeo, DL, Hunninghake, GM, Litonjua, AA, Sparrow, D, Lange, C, Won, S, Murphy, JR, Beaty, TL, Regan, EA, Make, BJ, Hokanson, JE, Crapo, JD, Kong, X, Anderson, WH, Tal-Singer, R, Lomas, DA, Bakke, P, Gulsvik, A, Pillai, SG & Silverman, EK 2010, 'Variants in FAM13A are associated with chronic obstructive pulmonary disease', Nature Genetics, vol. 42, no. 3, pp. 200-202. https://doi.org/10.1038/ng.535
Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nature Genetics. 2010 Mar;42(3):200-202. https://doi.org/10.1038/ng.535
Cho, Michael H. ; Boutaoui, Nadia ; Klanderman, Barbara J. ; Sylvia, Jody S. ; Ziniti, John P. ; Hersh, Craig P. ; Demeo, Dawn L. ; Hunninghake, Gary M. ; Litonjua, Augusto A. ; Sparrow, David ; Lange, Christoph ; Won, Sungho ; Murphy, James R. ; Beaty, Terri L ; Regan, Elizabeth A. ; Make, Barry J. ; Hokanson, John E. ; Crapo, James D. ; Kong, Xiangyang ; Anderson, Wayne H. ; Tal-Singer, Ruth ; Lomas, David A. ; Bakke, Per ; Gulsvik, Amund ; Pillai, Sreekumar G. ; Silverman, E. K. / Variants in FAM13A are associated with chronic obstructive pulmonary disease. In: Nature Genetics. 2010 ; Vol. 42, No. 3. pp. 200-202.
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AU - Tal-Singer, Ruth

AU - Lomas, David A.

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AU - Pillai, Sreekumar G.

AU - Silverman, E. K.

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