Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping

Priya B. Shetty, Hua Tang, Bamidele O. Tayo, Alanna C. Morrison, Craig L. Hanis, Dabeeru C. Rao, Jeffery H. Young, Ervin R. Fox, Eric Boerwinkle, Richard S. Cooper, Neil J. Risch, Xiaofeng Zhu

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Genetic variants in 296 genes in regions identified through admixture mapping of hypertension, BMI, and lipids were assessed for association with hypertension, blood pressure (BP), BMI, and high-density lipoprotein cholesterol (HDL-C). METHODS: This study identified coding SNPs identified from HapMap2 data that were located in genes on chromosomes 5, 6, 8, and 21, wherein ancestry association evidence for hypertension, BMI, or HDL-C was identified in previous admixture mapping studies. Genotyping was performed in 1733 unrelated African-Americans from the National Heart, Lung and Blood Institute's Family Blood Pressure Project, and gene-based association analyses were conducted for hypertension, SBP, DBP, BMI, and HDL-C. A gene score based on the number of minor alleles of each SNP in a gene was created and used for gene-based regression analyses, adjusting for age, age, sex, local marker ancestry, and BMI, as applicable. An individual's African ancestry estimated from 2507 ancestry-informative markers was also adjusted for to eliminate any confounding due to population stratification. RESULTS: CXADR (rs437470) on chromosome 21 was associated with SBP and DBP with or without adjusting for local ancestry (P<0.0006). F2RL1 (rs631465) on chromosome 5 was associated with BMI (P=0.0005). Local ancestry in these regions was associated with the respective traits as well. CONCLUSION: This study suggests that CXADR and F2RL1 likely play important roles in BP and obesity variation, respectively; and these findings are consistent with those of other studies, so replication and functional analyses are necessary.

Original languageEnglish (US)
Pages (from-to)1970-1976
Number of pages7
JournalJournal of hypertension
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2012

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Keywords

  • African-Americans
  • blood pressure
  • genetic association studies
  • obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Shetty, P. B., Tang, H., Tayo, B. O., Morrison, A. C., Hanis, C. L., Rao, D. C., Young, J. H., Fox, E. R., Boerwinkle, E., Cooper, R. S., Risch, N. J., & Zhu, X. (2012). Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping. Journal of hypertension, 30(10), 1970-1976. https://doi.org/10.1097/HJH.0b013e3283578c80