Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptor polymorphisms in control and disease populations

Thomas Lehrnbecher, Charles B. Foster, Shaoxian Zhu, Susan F. Leitman, Lynn R. Goldin, Konrad Huppi, Stephen J. Chanock

Research output: Contribution to journalArticle

Abstract

Fcγ-receptors (FcγR) provide a critical link between humoral and cellular immunity. The genes of the low-affinity receptors for IgG and their isoforms, namely, FcγRIIa, FcγRIIb, FcγRIIIa, FcγRIIIb, and SH-FcγRIIIb, are located in close proximity on chromosome 1q22. Variant alleles may differ in biologic activity and a number of studies have reported the frequencies of variant FcγR alleles in both disease and control populations. No large study has evaluated the possibility of a nonrandom distribution of variant genotypes. We analyzed 395 normal individuals (172 African Americans [AA] and 223 Caucasians [CA]) at the following loci: FcγRIIa, FcγRIIIa, and FcγRIIIb, including the SH-FcγRIIIb. The genotypic distributions of FcγRIIa, FcγRIIIa, and FcγRIIIb conform to the Hardy-Weinberg law in each group. There was no strong evidence that combinations of 2-locus genotypes of the 3 loci deviated from random distributions in these healthy control populations. The distribution of SH-FcγRIIIb is underrepresented in CA compared with AA (P <.0001) controls. A previously reported variant FcγRIIb was not detected in 70 normal individuals, indicating that this allele, if it exists, is very rare (<1%). In conclusion, we present data that should serve as the foundation for the interpretation of association studies involving multiple variant alleles of the low-affinity FcγR.

Original languageEnglish (US)
Pages (from-to)4220-4232
Number of pages13
JournalBlood
Volume94
Issue number12
StatePublished - Dec 15 1999
Externally publishedYes

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Fc Receptors
Polymorphism
Alleles
Genotype
African Americans
Population
IgG Receptors
Chromosomes
Protein Isoforms
Humoral Immunity
Genes
Cellular Immunity

ASJC Scopus subject areas

  • Hematology

Cite this

Lehrnbecher, T., Foster, C. B., Zhu, S., Leitman, S. F., Goldin, L. R., Huppi, K., & Chanock, S. J. (1999). Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptor polymorphisms in control and disease populations. Blood, 94(12), 4220-4232.

Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptor polymorphisms in control and disease populations. / Lehrnbecher, Thomas; Foster, Charles B.; Zhu, Shaoxian; Leitman, Susan F.; Goldin, Lynn R.; Huppi, Konrad; Chanock, Stephen J.

In: Blood, Vol. 94, No. 12, 15.12.1999, p. 4220-4232.

Research output: Contribution to journalArticle

Lehrnbecher, T, Foster, CB, Zhu, S, Leitman, SF, Goldin, LR, Huppi, K & Chanock, SJ 1999, 'Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptor polymorphisms in control and disease populations', Blood, vol. 94, no. 12, pp. 4220-4232.
Lehrnbecher, Thomas ; Foster, Charles B. ; Zhu, Shaoxian ; Leitman, Susan F. ; Goldin, Lynn R. ; Huppi, Konrad ; Chanock, Stephen J. / Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptor polymorphisms in control and disease populations. In: Blood. 1999 ; Vol. 94, No. 12. pp. 4220-4232.
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