Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men

Thomas Lehrnbecher, Charles B. Foster, Shaoxian Zhu, David Venzon, Seth M. Steinberg, Kathleen Wyvill, Julia A. Metcalf, Sandra S. Cohen, Joseph Kovacs, Robert Yarchoan, Andrew Blauvelt, Stephen J. Chanock

Research output: Contribution to journalArticle

Abstract

Disturbances in Inflammatory cytokine production and Immune regulation coupled with human herpesvirus-8 (HHV-8) infection underlie the current understanding of the pathogenesis of Kaposi's sarcoma (KS), the most common HIV-associated malignancy. The low affinity Fc gamma receptors (FcγR) for IgG link humoral and cellular immunity by mediating interaction between antibodies and effector cells, such as phagocytes and natural killer cells. We examined the frequency of polymorphic forms of the low affinity FcγRs, FcRIIA, FcγRIIIA, and FcγRIIIB in 2 cohorts of HIV-infected men with KS and found that the FcγRIIIA genotype exerts a significant Influence on susceptibility to or protection from KS. The FF genotype was underrepresented in patients with KS, whereas the VF genotype was associated with development of KS. A similar association was observed between FcγRIIIA genotypes and HHV-8 seropositivity. These observations suggest a possible role for FcγRIIIA in the development of KS during HIV infection. (C) 2000 by The American Society of Hematology.

Original languageEnglish (US)
Pages (from-to)2386-2390
Number of pages5
JournalBlood
Volume95
Issue number7
StatePublished - Apr 1 2000
Externally publishedYes

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IgG Receptors
Kaposi's Sarcoma
Immunoglobulin G
Genotype
HIV
Cytokines
Antibodies
Human Herpesvirus 8
Herpesviridae Infections
HIV-2
Phagocytes
Humoral Immunity
Cellular Immunity
Natural Killer Cells
HIV Infections
Neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

Lehrnbecher, T., Foster, C. B., Zhu, S., Venzon, D., Steinberg, S. M., Wyvill, K., ... Chanock, S. J. (2000). Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men. Blood, 95(7), 2386-2390.

Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men. / Lehrnbecher, Thomas; Foster, Charles B.; Zhu, Shaoxian; Venzon, David; Steinberg, Seth M.; Wyvill, Kathleen; Metcalf, Julia A.; Cohen, Sandra S.; Kovacs, Joseph; Yarchoan, Robert; Blauvelt, Andrew; Chanock, Stephen J.

In: Blood, Vol. 95, No. 7, 01.04.2000, p. 2386-2390.

Research output: Contribution to journalArticle

Lehrnbecher, T, Foster, CB, Zhu, S, Venzon, D, Steinberg, SM, Wyvill, K, Metcalf, JA, Cohen, SS, Kovacs, J, Yarchoan, R, Blauvelt, A & Chanock, SJ 2000, 'Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men', Blood, vol. 95, no. 7, pp. 2386-2390.
Lehrnbecher T, Foster CB, Zhu S, Venzon D, Steinberg SM, Wyvill K et al. Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men. Blood. 2000 Apr 1;95(7):2386-2390.
Lehrnbecher, Thomas ; Foster, Charles B. ; Zhu, Shaoxian ; Venzon, David ; Steinberg, Seth M. ; Wyvill, Kathleen ; Metcalf, Julia A. ; Cohen, Sandra S. ; Kovacs, Joseph ; Yarchoan, Robert ; Blauvelt, Andrew ; Chanock, Stephen J. / Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men. In: Blood. 2000 ; Vol. 95, No. 7. pp. 2386-2390.
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