Variable effects of aging on frontal lobe contributions to memory

Allyson C. Rosen, Matthew W. Prull, Ruth O'Hara, Elizabeth A. Race, John E. Desmond, Gary H. Glover, Jerome A. Yesavage, John D.E. Gabrieli

Research output: Contribution to journalArticle

Abstract

Declarative memory declines with age, but there is profound variation in the severity of this decline. Healthy elderly adults with high or low memory scores and young adults viewed words under semantic or non-semantic encoding conditions while undergoing fMRI. Young adults had superior memory for the words, and elderly adults with high memory scores had better memory for the words than those with low memory scores. The elderly with high scores had left lateral and medial prefrontal activations for semantic encoding equal to the young, and greater right prefrontal activation than the young. The elderly with low scores had reduced activations in all three regions relative to the elderly with high memory scores. Thus, successful aging was characterized by preserved left prefrontal and enhanced right prefrontal activation that may have provided compensatory encoding resources.

Original languageEnglish (US)
Pages (from-to)2425-2428
Number of pages4
JournalNeuroreport
Volume13
Issue number18
DOIs
StatePublished - Dec 20 2002
Externally publishedYes

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Keywords

  • Ageing
  • Encoding
  • Memory
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rosen, A. C., Prull, M. W., O'Hara, R., Race, E. A., Desmond, J. E., Glover, G. H., Yesavage, J. A., & Gabrieli, J. D. E. (2002). Variable effects of aging on frontal lobe contributions to memory. Neuroreport, 13(18), 2425-2428. https://doi.org/10.1097/00001756-200212200-00010