Variability of the homeostatic response to altered p50

S. Charache; S. Achuff; R. Winslow; J. Adamson; P. Chervenick

doi:10.1182/blood.v52.6.1156.1156

Variability of the homeostatic response to altered p₅₀

S. Charache, S. Achuff, R. Winslow, J. Adamson, P. Chervenick

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Blood from carriers of hemoglobin Osler (Hb Osler) had almost the same oxygen affinity as that of carrier s of Hb McKees Rocks (Hb MR) (P₅₀ 10-11 mm Hg), but Hb concentrations were higher in male carriers of the former (21.6 versus 17.2 g/dl). Two carriers of each Hb were studied to compare their adaptations to altered oxygen affinity and their responses to phlebotomy. All four were healthy, and all excreted normal amounts of erythropoietin. Carriers of Hb MR had somewhat lower mixed venous pO₂ than carriers of Hb Osler. There was no suggestion that phlebotomy impaired ability to exercise in either group of patients.

Original language	English (US)
Pages (from-to)	1156-1162
Number of pages	7
Journal	Unknown Journal
Volume	52
Issue number	6
DOIs	https://doi.org/10.1182/blood.v52.6.1156.1156
State	Published - 1978

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v52.6.1156.1156

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title = "Variability of the homeostatic response to altered p50",

abstract = "Blood from carriers of hemoglobin Osler (Hb Osler) had almost the same oxygen affinity as that of carrier s of Hb McKees Rocks (Hb MR) (P50 10-11 mm Hg), but Hb concentrations were higher in male carriers of the former (21.6 versus 17.2 g/dl). Two carriers of each Hb were studied to compare their adaptations to altered oxygen affinity and their responses to phlebotomy. All four were healthy, and all excreted normal amounts of erythropoietin. Carriers of Hb MR had somewhat lower mixed venous pO2 than carriers of Hb Osler. There was no suggestion that phlebotomy impaired ability to exercise in either group of patients.",

author = "S. Charache and S. Achuff and R. Winslow and J. Adamson and P. Chervenick",

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T1 - Variability of the homeostatic response to altered p50

AU - Charache, S.

AU - Achuff, S.

AU - Winslow, R.

AU - Adamson, J.

AU - Chervenick, P.

PY - 1978

Y1 - 1978

N2 - Blood from carriers of hemoglobin Osler (Hb Osler) had almost the same oxygen affinity as that of carrier s of Hb McKees Rocks (Hb MR) (P50 10-11 mm Hg), but Hb concentrations were higher in male carriers of the former (21.6 versus 17.2 g/dl). Two carriers of each Hb were studied to compare their adaptations to altered oxygen affinity and their responses to phlebotomy. All four were healthy, and all excreted normal amounts of erythropoietin. Carriers of Hb MR had somewhat lower mixed venous pO2 than carriers of Hb Osler. There was no suggestion that phlebotomy impaired ability to exercise in either group of patients.

AB - Blood from carriers of hemoglobin Osler (Hb Osler) had almost the same oxygen affinity as that of carrier s of Hb McKees Rocks (Hb MR) (P50 10-11 mm Hg), but Hb concentrations were higher in male carriers of the former (21.6 versus 17.2 g/dl). Two carriers of each Hb were studied to compare their adaptations to altered oxygen affinity and their responses to phlebotomy. All four were healthy, and all excreted normal amounts of erythropoietin. Carriers of Hb MR had somewhat lower mixed venous pO2 than carriers of Hb Osler. There was no suggestion that phlebotomy impaired ability to exercise in either group of patients.

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Variability of the homeostatic response to altered p₅₀

Abstract

ASJC Scopus subject areas

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