Variability of ischemia during spermatic cord torsion in the rat

R. A. Costabile, P. L. Choyke, J. A. Frank, M. E. Girton, R. Diggs, Kevin Lenuell Billups, C. Desjardins

Research output: Contribution to journalArticle

Abstract

Testicular torsion affects prepubertal males and causes testicular infarction and subfertility. Animal models of spermatic cord torsion have been used in an attempt to study the mechanism of testicular injury from torsion. Although standardized animal models of torsion have been proposed, their reliability in producing testicular ischemia has not been documented. Dynamic enhanced magnetic resonance imaging (MRI) of the testis was used in a rat model with surgically induced, unilateral, 720° torsion to quantify the severity of ischemia. Intravenous dysprosium diethylenetriaminepentaacetic acid-bis methylamide (Dy-DTPA-BMA) was injected as a bolus followed by serial dynamic Turbo GRASS images. Region of interest (ROI) measurements were obtained within the testicular parenchyma during contrast enhancement and washout. Perfusion abnormalities ranging from minimal delay in contrast enhancement in the torqued testicle to complete absence of intraparenchymal blood flow were documented with dynamic enhanced MRI. Reperfusion scans 1 hour after surgical reduction of torsion showed normalization of testicular blood flow in all animals. Dynamic enhanced MRI appears to be a useful method of documenting the perfusion deficit arising from torsion of the testis. Standard animal models of torsion produce inconsistent results because they do not reliably reproduce testicular ischemia. The ability of MRI to quantify perfusion abnormalities in the testis may provide additional information in the evaluation of human patients with symptoms of testicular torsion.

Original languageEnglish (US)
Pages (from-to)1070-1072
Number of pages3
JournalJournal of Urology
Volume151
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Spermatic Cord Torsion
Testis
Ischemia
Magnetic Resonance Imaging
Animal Models
Perfusion
sprodiamide
Infarction
Infertility
Reperfusion
Wounds and Injuries

Keywords

  • blood flow velocity
  • infertility
  • perfusion
  • testis

ASJC Scopus subject areas

  • Urology

Cite this

Costabile, R. A., Choyke, P. L., Frank, J. A., Girton, M. E., Diggs, R., Billups, K. L., & Desjardins, C. (1994). Variability of ischemia during spermatic cord torsion in the rat. Journal of Urology, 151(4), 1070-1072.

Variability of ischemia during spermatic cord torsion in the rat. / Costabile, R. A.; Choyke, P. L.; Frank, J. A.; Girton, M. E.; Diggs, R.; Billups, Kevin Lenuell; Desjardins, C.

In: Journal of Urology, Vol. 151, No. 4, 1994, p. 1070-1072.

Research output: Contribution to journalArticle

Costabile, RA, Choyke, PL, Frank, JA, Girton, ME, Diggs, R, Billups, KL & Desjardins, C 1994, 'Variability of ischemia during spermatic cord torsion in the rat', Journal of Urology, vol. 151, no. 4, pp. 1070-1072.
Costabile RA, Choyke PL, Frank JA, Girton ME, Diggs R, Billups KL et al. Variability of ischemia during spermatic cord torsion in the rat. Journal of Urology. 1994;151(4):1070-1072.
Costabile, R. A. ; Choyke, P. L. ; Frank, J. A. ; Girton, M. E. ; Diggs, R. ; Billups, Kevin Lenuell ; Desjardins, C. / Variability of ischemia during spermatic cord torsion in the rat. In: Journal of Urology. 1994 ; Vol. 151, No. 4. pp. 1070-1072.
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