TY - JOUR
T1 - Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm3 (ACTG 175)
AU - Lathey, Janet L.
AU - Hughes, Michael D.
AU - Fiscus, Susan A.
AU - Pi, Timothy
AU - Brooks Jackson, J.
AU - Rasheed, Suraiya
AU - Elbeik, Tarek
AU - Reichman, Richard
AU - Japour, Anthony
AU - D'Aquila, Richard T.
AU - Scott, Walter
AU - Griffith, Brigitte P.
AU - Hammer, Scott M.
AU - Katzenstein, David A.
PY - 1998
Y1 - 1998
N2 - Virologic measurements are increasingly used to evaluate prognosis and treatment responses in human immunodeficiency virus (HIV) type 1 infection. Markers of HIV-1 replication, including infectious HIV-1 titer from peripheral blood mononuclear cells, serum HIV-1 p24 antigen, plasma HIV-1 RNA, CD4 cell numbers, and viral syncytium-inducing (SI) phenotype, were determined in 391 virology substudy participants in AIDS Clinical Trials Group study 175. The subjects had 200-500 CD4 cells/mm3. All markers of viral replication significantly correlated with one another and were inversely related to CD4 cell number. Disease progression to an AIDS-defining event or death or loss of >50% of CD4 cells was associated with infectious HIV-1 titer (P <.001), HIV-1 RNA (P <.001), and HIV-1 p24 antigen (P = .007). In multivariate proportional hazards models, p24 antigen was never significant when HIV-1 RNA level was included. In a model containing infectious HIV-1 titer (P = .038), HIV-1 RNA (P <.001), SI phenotype (P <.001), and CD4 cell number (P = .18), only the virologic parameters remained significantly associated with progression.
AB - Virologic measurements are increasingly used to evaluate prognosis and treatment responses in human immunodeficiency virus (HIV) type 1 infection. Markers of HIV-1 replication, including infectious HIV-1 titer from peripheral blood mononuclear cells, serum HIV-1 p24 antigen, plasma HIV-1 RNA, CD4 cell numbers, and viral syncytium-inducing (SI) phenotype, were determined in 391 virology substudy participants in AIDS Clinical Trials Group study 175. The subjects had 200-500 CD4 cells/mm3. All markers of viral replication significantly correlated with one another and were inversely related to CD4 cell number. Disease progression to an AIDS-defining event or death or loss of >50% of CD4 cells was associated with infectious HIV-1 titer (P <.001), HIV-1 RNA (P <.001), and HIV-1 p24 antigen (P = .007). In multivariate proportional hazards models, p24 antigen was never significant when HIV-1 RNA level was included. In a model containing infectious HIV-1 titer (P = .038), HIV-1 RNA (P <.001), SI phenotype (P <.001), and CD4 cell number (P = .18), only the virologic parameters remained significantly associated with progression.
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M3 - Article
C2 - 9498440
AN - SCOPUS:17344371054
SN - 0022-1899
VL - 177
SP - 617
EP - 624
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -