Vanishing bile duct syndrome refers to a group of disorders characterised by progressive destruction of the intrahepatic bile ducts resulting in cholestasis. It is a fi nal common pathway for many disorders. The diagnoses is mainly made by histological fi ndings. To consider a diagnosis there should be loss of interlobular bile ducts in more than fi fty per cent of small portal tracts provided that the specimen contains at least 10 portal tracts. Here the authors present a case of vanishing bile duct syndrome which developed after initiation of highly active antiretroviral treatment therapy.
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