TY - JOUR
T1 - Vanilloid receptors take a TRP beyond the sensory afferent
AU - Caterina, Michael J.
N1 - Funding Information:
Supported by The American Cancer Society (RSG-01-063-01-CSM).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/9
Y1 - 2003/9
N2 - TRPV1 expression extends to a number of cells besides cutaneous afferents, suggesting functions for this molecule in diverse sensory and non-sensory processes. Possible side effects related to visceral, thermoregulatory, cognitive, motor, or emotional functions must therefore be considered during the development of therapeutic strategies involving the systemic administration of agents active at TRPV1. Proper dosing and biodistribution will undoubtedly be critical parameters in these strategies, as in others aimed at molecules presumed to be 'nociceptor-specific'.
AB - TRPV1 expression extends to a number of cells besides cutaneous afferents, suggesting functions for this molecule in diverse sensory and non-sensory processes. Possible side effects related to visceral, thermoregulatory, cognitive, motor, or emotional functions must therefore be considered during the development of therapeutic strategies involving the systemic administration of agents active at TRPV1. Proper dosing and biodistribution will undoubtedly be critical parameters in these strategies, as in others aimed at molecules presumed to be 'nociceptor-specific'.
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U2 - 10.1016/S0304-3959(03)00259-8
DO - 10.1016/S0304-3959(03)00259-8
M3 - Review article
C2 - 14499414
AN - SCOPUS:0141738818
SN - 0304-3959
VL - 105
SP - 5
EP - 9
JO - Pain
JF - Pain
IS - 1-2
ER -