Validity testing of the TDX® cocaine metabolite assay with human specimens obtained after intravenous cocaine administration

Edward J. Cone, Sandra L. Menchen, John Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical specimens obtained from human subjects after intravenous cocaine administration were analyzed by the TDx® Cocaine Metabolite Assay (TDx) and by GC MS for benzoylecgonine. The TDx results were significantly correlated with results by GC MS assay with no evidence of bias in the TDx assay. All cocaine metabolite positive specimens (≥300 ng/ml) were confirmed by GC MS. Detection times to the last positive specimen by TDx assay and GC MS assay for four subjects after a 20-mg intravenous dose of cocaine ranged from 29.3 to 39.1 h and 27.9 to 36.6 h, respectively. Overall, the TDx assay was found to be highly specific and accurate for the detection and measurement of benzoylecgonine in urine.

Original languageEnglish (US)
Pages (from-to)265-275
Number of pages11
JournalForensic Science International
Volume37
Issue number4
DOIs
StatePublished - Jun 1988

Keywords

  • Cocaine
  • TDx assay
  • Urine screening
  • Validity testing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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