TY - JOUR
T1 - Validity of estimated dietary eicosapentaenoic acid and docosahexaenoic acid intakes determined by interviewer-administered food frequency questionnaire among older adults with mild-to-moderate cognitive impairment or dementia
AU - Arsenault, Lisa N.
AU - Matthan, Nirupa
AU - Scott, Tammy M.
AU - Dallal, Gerard
AU - Lichtenstein, Alice H.
AU - Folstein, Marshal F.
AU - Rosenberg, Irwin
AU - Tucker, Katherine L.
PY - 2009/7
Y1 - 2009/7
N2 - Epidemiologic research is increasingly being focused on elderly persons, many of whom exhibit mild-to-moderate cognitive impairment. This presents a challenge for collection and interpretation of self-reported dietary data. There are few reports on the impact of cognitive function and dementia on the validity of self-reported dietary intakes. Using plasma phospholipid fatty acid profiles as a biomarker of intake, the authors assessed the validity of an interviewer-administered food frequency questionnaire (FFQ) to estimate intakes of 2 marine-based omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among 273 community-dwelling adults aged ≥60 years participating in the Nutrition, Aging, and Memory in Elders Study (Boston, Massachusetts, 2002-2008). Age- and energy-adjusted Pearson correlation coefficients for correlations between dietary intakes and plasma phospholipids were consistent across categories of high and low cognitive function (r =0.48), based on Mini-Mental State Examination score, and were similar across clinically diagnosed categories of normal functioning (r =0.49), mild cognitive impairment (r =0.45), and dementia (r =0.52). The FFQ ranked 78% of subjects to within 1 quartile of their plasma phospholipid EPA + DHA quartile. This frequency was consistently high across all cognitive categories. With interviewer administration, this FFQ seems to be a valid method of assessing dietary EPA + DHA intake in older adults with mild-to-moderate cognitive impairment.
AB - Epidemiologic research is increasingly being focused on elderly persons, many of whom exhibit mild-to-moderate cognitive impairment. This presents a challenge for collection and interpretation of self-reported dietary data. There are few reports on the impact of cognitive function and dementia on the validity of self-reported dietary intakes. Using plasma phospholipid fatty acid profiles as a biomarker of intake, the authors assessed the validity of an interviewer-administered food frequency questionnaire (FFQ) to estimate intakes of 2 marine-based omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among 273 community-dwelling adults aged ≥60 years participating in the Nutrition, Aging, and Memory in Elders Study (Boston, Massachusetts, 2002-2008). Age- and energy-adjusted Pearson correlation coefficients for correlations between dietary intakes and plasma phospholipids were consistent across categories of high and low cognitive function (r =0.48), based on Mini-Mental State Examination score, and were similar across clinically diagnosed categories of normal functioning (r =0.49), mild cognitive impairment (r =0.45), and dementia (r =0.52). The FFQ ranked 78% of subjects to within 1 quartile of their plasma phospholipid EPA + DHA quartile. This frequency was consistently high across all cognitive categories. With interviewer administration, this FFQ seems to be a valid method of assessing dietary EPA + DHA intake in older adults with mild-to-moderate cognitive impairment.
KW - Aged
KW - Aged 80 and over
KW - Dementia
KW - Epidemiologic methods
KW - Fatty acids
KW - Mental recall
KW - Nutrition assessment
KW - Omega-3
KW - Questionnaires
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U2 - 10.1093/aje/kwp089
DO - 10.1093/aje/kwp089
M3 - Article
C2 - 19433614
AN - SCOPUS:67650021836
VL - 170
SP - 95
EP - 103
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 1
ER -