TY - JOUR
T1 - Validation of the Saint George's Respiratory Questionnaire in Uganda
AU - Morgan, Brooks W.
AU - Grigsby, Matthew R.
AU - Siddharthan, Trishul
AU - Kalyesubula, Robert
AU - Wise, Robert A.
AU - Hurst, John R.
AU - Kirenga, Bruce
AU - Checkley, William
N1 - Funding Information:
Acknowledgements The LiNK study was conducted by Johns Hopkins University (USA) in close collaboration with ACCESS Uganda and the Makerere Lung Institute, Makerere University (Uganda). This project was supported by NIH Research Training Grant #D43 TW009340 funded by the NIH Fogarty International Center, NINDS, NIMH, NHLBI, and NIEHS, the COPD Discovery Fund from Johns Hopkins University, and the Johns Hopkins Center for Global Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Analysis of the validation of the SGRQ instrument in Uganda was supported in part by the Medical Research Council (MR/ P008984/1, PI: Hurst). We thank Faith Nassali and Denis Mawanda for making the study possible. Finally, we thank the participants of the LiNK cohort study.
Funding Information:
Funding This project was supported by NIH Research Training Grant #D43 TW009340 funded by the NIH Fogarty International Center, NINDS, NIMH, NHLBI, and NIEHS, the COPD Discovery Fund from Johns Hopkins University, and the Johns Hopkins Center for Global Health. Analysis of the validation of the SGRQ instrument in Uganda was supported in part by the Medical Research Council (MR/P008984/1, PI: Hurst).
Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Introduction Chronic obstructive pulmonary disease (COPD) will soon be the third leading global cause of death and is increasing rapidly in low/middle-income countries. There is a need for local validation of the Saint George's Respiratory Questionnaire (SGRQ), which can be used to identify those experiencing lifestyle impairment due to their breathing. Methods The SGRQ was professionally translated into Luganda and reviewed by our field staff and a local pulmonologist. Participants included a COPD-confirmed clinic sample and COPD-positive and negative members of the community who were enrolled in the Lung Function in Nakaseke and Kampala (LiNK) Study. SGRQs were assembled from all participants, while demographic and spirometry data were additionally collected from LiNK participants. Results In total, 103 questionnaires were included in analysis: 49 with COPD from clinic, 34 community COPD-negative and 20 community COPD-positive. SGRQ score varied by group: 53.5 for clinic, 34.4 for community COPD-positive and 4.1 for community COPD-negative (p<0.001). The cross-validated c statistic for SGRQ total score predicting COPD was 0.87 (95% CI 0.75 to 1.00). SGRQ total score was associated with COPD severity (forced expiratory volume in 1 s per cent of predicted), with an r coefficient of -0.60 (-0.75, -0.39). SGRQ score was associated with dyspnoea (OR 1.05/point; 1.01, 1.09) and cough (1.07; 1.03, 1.11). Conclusion Our Luganda language SGRQ accurately distinguishes between COPD-positive and negative community members in rural Uganda. Scores were correlated with COPD severity and were associated with odds of dyspnoea and cough. We find that it can be successfully used as a respiratory questionnaire for obstructed adults in Uganda.
AB - Introduction Chronic obstructive pulmonary disease (COPD) will soon be the third leading global cause of death and is increasing rapidly in low/middle-income countries. There is a need for local validation of the Saint George's Respiratory Questionnaire (SGRQ), which can be used to identify those experiencing lifestyle impairment due to their breathing. Methods The SGRQ was professionally translated into Luganda and reviewed by our field staff and a local pulmonologist. Participants included a COPD-confirmed clinic sample and COPD-positive and negative members of the community who were enrolled in the Lung Function in Nakaseke and Kampala (LiNK) Study. SGRQs were assembled from all participants, while demographic and spirometry data were additionally collected from LiNK participants. Results In total, 103 questionnaires were included in analysis: 49 with COPD from clinic, 34 community COPD-negative and 20 community COPD-positive. SGRQ score varied by group: 53.5 for clinic, 34.4 for community COPD-positive and 4.1 for community COPD-negative (p<0.001). The cross-validated c statistic for SGRQ total score predicting COPD was 0.87 (95% CI 0.75 to 1.00). SGRQ total score was associated with COPD severity (forced expiratory volume in 1 s per cent of predicted), with an r coefficient of -0.60 (-0.75, -0.39). SGRQ score was associated with dyspnoea (OR 1.05/point; 1.01, 1.09) and cough (1.07; 1.03, 1.11). Conclusion Our Luganda language SGRQ accurately distinguishes between COPD-positive and negative community members in rural Uganda. Scores were correlated with COPD severity and were associated with odds of dyspnoea and cough. We find that it can be successfully used as a respiratory questionnaire for obstructed adults in Uganda.
KW - COPD epidemiology
KW - respiratory measurement
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U2 - 10.1136/bmjresp-2018-000276
DO - 10.1136/bmjresp-2018-000276
M3 - Article
C2 - 30018764
AN - SCOPUS:85049935868
SN - 2052-4439
VL - 5
JO - BMJ Open Respiratory Research
JF - BMJ Open Respiratory Research
IS - 1
M1 - e000276
ER -