Validation of 19f‐magnetic resonance determination of myocardial blood volume

Gerald A. Rottman, Robert M. Judd, Frank C.P. Yin

Research output: Contribution to journalArticlepeer-review

Abstract

The use of perfluorochemical (PFC) emulsions to study the myocardial circulation by means of 19F NMR requires that the biodistribution of the PFC be known. The authors tested the hypothesis that PFC particles remain within the myocardial vascular space by infusing rats with both a PFC emulsion and 125I‐albumin. Measurement of myocardial vascular volume by 19F NMR and by standard radiotracer analysis of the same tissue yielded concordant values by the two methods, establishing the PFC emulsion as an intravascular agent in this tissue. Perfluorochemical emulsions should be useful for the noninvasive study of myocardial vascular physiology by magnetic resonance.

Original languageEnglish (US)
Pages (from-to)628-631
Number of pages4
JournalMagnetic resonance in medicine
Volume34
Issue number4
DOIs
StatePublished - Oct 1995

Keywords

  • NMR
  • blood
  • myocardium
  • perfluorochemical

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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