TY - JOUR
T1 - Validation of Outcome Instruments for Pediatric Postthrombotic Syndrome
T2 - Introducing the Peds-VEINES-QOL, a New Health-Related Quality of Life Instrument
AU - Smith, Julie
AU - Thornhill, Dianne
AU - Goldenberg, Neil A.
AU - Brandão, Leonardo
AU - Knapp-Clevenger, Rhonda
AU - Warren, Beth Boulden
AU - Sung, Lillian
AU - Kahn, Susan R.
AU - Manco-Johnson, Marilyn
N1 - Publisher Copyright:
© 2021 Georg Thieme Verlag. All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background There is need for validated outcome measures for postthrombotic syndrome (PTS) following pediatric venous thromboembolism (VTE), with a focus on quality of life (QoL). Aims This article assesses reliability and validity of two PTS and two QoL scales for children following lower extremity VTE. Methods Pediatric patients following lower extremity VTE were recruited from three thrombosis clinics. The Manco-Johnson (MJ) and the modified Villalta (MV) PTS scales were compared with each other and with the generic pediatric health-related QoL, PedsQL, and a newly developed pediatric venous-specific QoL, the Peds-VEINES-QOL. Results Eighty children following VTE and 60 healthy control children were enrolled. Internal consistency measured by Cronbach's α was high for the two QoL scales, and moderate for the two PTS scales. Inter-rater reliability using intraclass correlation coefficients was moderate to high for the MJ, MV, and Peds-VEINES-QOL, and moderate for the PedsQL. Evidence of high internal consistency by Cronbach's α coefficients, and moderate to high interitem correlations support the premise that a single construct was measured by each instrument. Correlations between the four instruments indicate convergent validity. Conclusion The MJ and MV scales detect similar outcomes in children following VTE. As used, the MJ is slightly more sensitive to QoL because a positive diagnosis requires pain which is the leading factor in reduced QoL following deep vein thrombosis. When using the MV, a requirement for pain or abnormal use to diagnose PTS would make the MV a better predictor of QoL.
AB - Background There is need for validated outcome measures for postthrombotic syndrome (PTS) following pediatric venous thromboembolism (VTE), with a focus on quality of life (QoL). Aims This article assesses reliability and validity of two PTS and two QoL scales for children following lower extremity VTE. Methods Pediatric patients following lower extremity VTE were recruited from three thrombosis clinics. The Manco-Johnson (MJ) and the modified Villalta (MV) PTS scales were compared with each other and with the generic pediatric health-related QoL, PedsQL, and a newly developed pediatric venous-specific QoL, the Peds-VEINES-QOL. Results Eighty children following VTE and 60 healthy control children were enrolled. Internal consistency measured by Cronbach's α was high for the two QoL scales, and moderate for the two PTS scales. Inter-rater reliability using intraclass correlation coefficients was moderate to high for the MJ, MV, and Peds-VEINES-QOL, and moderate for the PedsQL. Evidence of high internal consistency by Cronbach's α coefficients, and moderate to high interitem correlations support the premise that a single construct was measured by each instrument. Correlations between the four instruments indicate convergent validity. Conclusion The MJ and MV scales detect similar outcomes in children following VTE. As used, the MJ is slightly more sensitive to QoL because a positive diagnosis requires pain which is the leading factor in reduced QoL following deep vein thrombosis. When using the MV, a requirement for pain or abnormal use to diagnose PTS would make the MV a better predictor of QoL.
KW - Manco-Johnson instrument
KW - Peds-VEINES-QOL
KW - PedsQL
KW - modified Villalta instrument
KW - pediatric VTE outcomes
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UR - http://www.scopus.com/inward/citedby.url?scp=85102614247&partnerID=8YFLogxK
U2 - 10.1055/s-0041-1725199
DO - 10.1055/s-0041-1725199
M3 - Article
C2 - 33706398
AN - SCOPUS:85102614247
SN - 0340-6245
VL - 121
SP - 1367
EP - 1375
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 10
ER -