Validation of genome-wide prostate cancer associations in men of african descent

Bao Li Chang; Elaine Spangler; Stephen Gallagher; Christopher A. Haiman; Brian Henderson; William Isaacs; Marnita L. Benford; Lacreis R. Kidd; Kathleen Cooney; Sara Strom; Sue Ann Ingles; Mariana C. Stern; Roman Corral; Amit D. Joshi; Jianfeng Xu; Veda N. Giri; Benjamin Rybicki; Christine Neslund-Dudas; Adam S. Kibel; Ian M. Thompson; Robin J. Leach; Elaine A. Ostrander; Janet L. Stanford; John Witte; Graham Casey; Rosalind Eeles; Ann W. Hsing; Stephen Chanock; Jennifer J. Hu; Esther M. John; Jong Park; Klara Stefflova; Charnita Zeigler-Johnson; Timothy R. Rebbeck

doi:10.1158/1055-9965.EPI-10-0698

Validation of genome-wide prostate cancer associations in men of african descent

Bao Li Chang, Elaine Spangler, Stephen Gallagher, Christopher A. Haiman, Brian Henderson, William Isaacs, Marnita L. Benford, Lacreis R. Kidd, Kathleen Cooney, Sara Strom, Sue Ann Ingles, Mariana C. Stern, Roman Corral, Amit D. Joshi, Jianfeng Xu, Veda N. Giri, Benjamin Rybicki, Christine Neslund-Dudas, Adam S. Kibel, Ian M. ThompsonRobin J. Leach, Elaine A. Ostrander, Janet L. Stanford, John Witte, Graham Casey, Rosalind Eeles, Ann W. Hsing, Stephen Chanock, Jennifer J. Hu, Esther M. John, Jong Park, Klara Stefflova, Charnita Zeigler-Johnson, Timothy R. Rebbeck

School of Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.

Original language	English (US)
Pages (from-to)	23-32
Number of pages	10
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	20
Issue number	1
DOIs	https://doi.org/10.1158/1055-9965.EPI-10-0698
State	Published - Jan 2011

ASJC Scopus subject areas

General Medicine

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Chang, B. L., Spangler, E., Gallagher, S., Haiman, C. A., Henderson, B., Isaacs, W., Benford, M. L., Kidd, L. R., Cooney, K., Strom, S., Ingles, S. A., Stern, M. C., Corral, R., Joshi, A. D., Xu, J., Giri, V. N., Rybicki, B., Neslund-Dudas, C., Kibel, A. S., ... Rebbeck, T. R. (2011). Validation of genome-wide prostate cancer associations in men of african descent. Cancer Epidemiology Biomarkers and Prevention, 20(1), 23-32. https://doi.org/10.1158/1055-9965.EPI-10-0698

Chang, BL, Spangler, E, Gallagher, S, Haiman, CA, Henderson, B, Isaacs, W, Benford, ML, Kidd, LR, Cooney, K, Strom, S, Ingles, SA, Stern, MC, Corral, R, Joshi, AD, Xu, J, Giri, VN, Rybicki, B, Neslund-Dudas, C, Kibel, AS, Thompson, IM, Leach, RJ, Ostrander, EA, Stanford, JL, Witte, J, Casey, G, Eeles, R, Hsing, AW, Chanock, S, Hu, JJ, John, EM, Park, J, Stefflova, K, Zeigler-Johnson, C & Rebbeck, TR 2011, 'Validation of genome-wide prostate cancer associations in men of african descent', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 1, pp. 23-32. https://doi.org/10.1158/1055-9965.EPI-10-0698

@article{7759dfe6594d4c81ab6f7a27035e38f1,

title = "Validation of genome-wide prostate cancer associations in men of african descent",

abstract = "Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.",

author = "Chang, {Bao Li} and Elaine Spangler and Stephen Gallagher and Haiman, {Christopher A.} and Brian Henderson and William Isaacs and Benford, {Marnita L.} and Kidd, {Lacreis R.} and Kathleen Cooney and Sara Strom and Ingles, {Sue Ann} and Stern, {Mariana C.} and Roman Corral and Joshi, {Amit D.} and Jianfeng Xu and Giri, {Veda N.} and Benjamin Rybicki and Christine Neslund-Dudas and Kibel, {Adam S.} and Thompson, {Ian M.} and Leach, {Robin J.} and Ostrander, {Elaine A.} and Stanford, {Janet L.} and John Witte and Graham Casey and Rosalind Eeles and Hsing, {Ann W.} and Stephen Chanock and Hu, {Jennifer J.} and John, {Esther M.} and Jong Park and Klara Stefflova and Charnita Zeigler-Johnson and Rebbeck, {Timothy R.}",

year = "2011",

month = jan,

doi = "10.1158/1055-9965.EPI-10-0698",

language = "English (US)",

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journal = "Cancer Epidemiology Biomarkers and Prevention",

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T1 - Validation of genome-wide prostate cancer associations in men of african descent

AU - Chang, Bao Li

AU - Spangler, Elaine

AU - Gallagher, Stephen

AU - Haiman, Christopher A.

AU - Henderson, Brian

AU - Isaacs, William

AU - Benford, Marnita L.

AU - Kidd, Lacreis R.

AU - Cooney, Kathleen

AU - Strom, Sara

AU - Ingles, Sue Ann

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Joshi, Amit D.

AU - Xu, Jianfeng

AU - Giri, Veda N.

AU - Rybicki, Benjamin

AU - Neslund-Dudas, Christine

AU - Kibel, Adam S.

AU - Thompson, Ian M.

AU - Leach, Robin J.

AU - Ostrander, Elaine A.

AU - Stanford, Janet L.

AU - Witte, John

AU - Casey, Graham

AU - Eeles, Rosalind

AU - Hsing, Ann W.

AU - Chanock, Stephen

AU - Hu, Jennifer J.

AU - John, Esther M.

AU - Park, Jong

AU - Stefflova, Klara

AU - Zeigler-Johnson, Charnita

AU - Rebbeck, Timothy R.

PY - 2011/1

Y1 - 2011/1

N2 - Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.

AB - Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.

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JO - Cancer Epidemiology Biomarkers and Prevention

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Validation of genome-wide prostate cancer associations in men of african descent

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