@article{4158a876f779416e93201af291bbf7d8,
title = "Validation of Biomarkers for Early Detection of Pancreatic Cancer: Summary of the Alliance of Pancreatic Cancer Consortia for Biomarkers for Early Detection Workshop",
abstract = "Pancreatic cancer is the third leading cause of cancer death in the United States, and the 5-year relative survival for patients diagnosed with pancreatic cancer is less than 10%. Early intervention is the key to a better survival outcome. Currently, there are no biomarkers that can reliably detect pancreatic cancer at an early stage or identify precursors that are destined to progress to malignancy. The National Cancer Institute in partnership with the Kenner Family Research Fund and the Pancreatic Cancer Action Network convened a Data Jamboree on Biomarkers workshop on December 5, 2016, to discuss and evaluate existing or newly developed biomarkers and imaging methods for early detection of pancreatic cancer. The primary goal of this workshop was to determine if there are any promising biomarkers for early detection of pancreatic cancer that are ready for clinical validation. The Alliance of Pancreatic Cancer Consortia for Biomarkers for Early Detection, formed under the auspices of this workshop, will provide the common platform and the resources necessary for validation. Although none of the biomarkers evaluated seemed ready for a large-scale biomarker validation trial, a number of them had sufficiently high sensitivity and specificity to warrant additional research, especially if combined with other biomarkers to form a panel.",
keywords = "PDAC, biomarkers, early detection, validation",
author = "Young, {Matthew R.} and Wagner, {Paul D.} and Sharmistha Ghosh and Rinaudo, {Jo Ann} and Baker, {Stuart G.} and Zaret, {Kenneth S.} and Michael Goggins and Sudhir Srivastava",
note = "Funding Information: Investigators from four NCI-supported consortia on pancreatic cancer detection, including the Pancreatic Cancer Detection Consortium (PCDC), the Early Detection Research Network (EDRN), the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), and the Consortium for Molecular Characterization of Screen-Detected Lesions (MCL), were invited to participate in the Data Jamboree on Biomarkers workshop. Other invited participants included NCI program directors, investigators supported by and members of the Kenner Family Research Fund and the Pancreatic Cancer Action Network, and investigators from industry. Biostatisticians from the NCI, Division of Cancer Prevention, Biometry Research Group, and the EDRN also participated. The expected outcome of this meeting was to identify biomarkers and/or imaging methods that could be further tested and validated through the PCDC and/or the EDRN, as part of The Alliance of Pancreatic Cancer Consortia for Biomarkers for Early Detection. Funding Information: From the *Cancer Biomarker Research Group and †Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, National Institute of Heath, Rockville, MD; ‡Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and §Departments of Pathology, Medicine, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD. Received for publication September 7, 2017; accepted November 13, 2017. Address correspondence to: Sudhir Srivastava, PhD, MPH, Cancer Biomarker Research Group, Division of Cancer Prevention, National Cancer Institute, National Institute of Heath, Rockville, MD 20850 (e‐mail: srivasts@mail.nih.gov). The workshop was jointly funded by the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, the Kenner Family Research Fund, and the Pancreatic Cancer Action Network. The authors declare no conflict of interest. Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MPA.0000000000000973 Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
month = feb,
day = "1",
doi = "10.1097/MPA.0000000000000973",
language = "English (US)",
volume = "47",
pages = "135--141",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "2",
}