Validation of an albuminuria self-assessment tool in the Multi-Ethnic Study of Atherosclerosis (MESA)

Rikki M. Tanner, Mark Woodward, Carmen Peralta, David G. Warnock, Orlando Gutiérrez, Daichi Shimbo, Holly Kramer, Ronit Katz, Paul Muntner

Research output: Contribution to journalArticle

Abstract

Objective: We previously developed an 8-item self-assessment tool to identify individuals with a high probability of having albuminuria. This tool was developed and externally validated among non-Hispanic Whites and non-Hispanic Blacks. We sought to validate it in a multi-ethnic cohort that also included Hispanics and Chinese Americans. Design: This is a cross-sectional study. Setting: Data were collected using standardized questionnaires and spot urine samples at a baseline examination in 2000- 2002. The 8 items in the self-assessment tool include age, race, gender, current cigarette smoking, history of diabetes, hypertension, or stroke, and self-rated health. Participants: Of 6,814 community-dwelling adults aged 45-84 years participating in the Multi-Ethnic Study of Atherosclerosis (MESA), 6,542 were included in the primary analysis. Main Outcome Measures: Albuminuria was defined as urine albumin-to-creatinine ratio ≥30 mg/g at baseline. Results: Among non-Hispanic Whites, non- Hispanic Blacks, Hispanics, and Chinese Americans, the prevalence of albuminuria was 6.0%, 11.3%, 11.6%, and 10.8%, respectively. The c-statistic for discriminating participants with and without albuminuria was .731 (95% CI: .692, .771), .728 (95% CI: .687, .761), .747 (95% CI: .709, .784), and .761 (95% CI: .699, .814) for non-Hispanic Whites, non-Hispanic Blacks, Hispanics, and Chinese Americans, respectively. The self-assessment tool over-estimated the probability of albuminuria for non-Hispanic Whites and Blacks, but was well-calibrated for Hispanics and Chinese Americans. Conclusions: The albuminuria self-assessment tool maintained good test characteristics in this large multi-ethnic cohort, suggesting it may be helpful for increasing awareness of albuminuria in an ethnically diverse population.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalEthnicity and Disease
Volume25
Issue number4
DOIs
StatePublished - Sep 1 2015

Keywords

  • Albuminuria
  • Ethnicity
  • Kidney Disease
  • Race
  • Racial Disparities
  • Screening
  • Self-assessment

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

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    Tanner, R. M., Woodward, M., Peralta, C., Warnock, D. G., Gutiérrez, O., Shimbo, D., Kramer, H., Katz, R., & Muntner, P. (2015). Validation of an albuminuria self-assessment tool in the Multi-Ethnic Study of Atherosclerosis (MESA). Ethnicity and Disease, 25(4), 427-434. https://doi.org/10.18865/ed.25.4.427