Validation of active breathing control in patients with non-small-cell lung cancer to be treated with CHARTWEL

Elena M. Wilson, F. Joy Williams, B. Ethan Lyn, John W. Wong, Edwin G.A. Aird

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Active breathing control (ABC) was validated using patients with non-small-cell lung cancer (NSCLC) to be treated with continuous hyperfractionated accelerated radiotherapy weekend-less (CHARTWEL). Effects of breath hold (BH) on accuracy and normal tissue doses were evaluated. Methods and Materials: Eleven patients were studied. Immediately after a free breathing (FB) planning scan, two ABC scans (ABC 1 and 2) were performed to assess intrafraction variation. A third ABC scan (ABC 3) was performed some weeks later to assess interfraction variation. Assisted BH was set at 75% of vital capacity and reproducibility assessed using computed tomography (CT) lung volumes. Planning target volumes (PTVs), doses to lung and spinal cord for FB and ABC 1 scans were compared. Results: Results were available for 10 patients. Disease and elective nodal regions were easier to define on ABC scans making PTVs smaller. ABC lung volumes showed no significant variation over several weeks, percentage volume of whole lung receiving ≥20 Gy (V20) was reduced in all (median 6.4%, p = 0.005), and spinal cord dose in 80% (median 1.03 Gy, p = 0.02), of the plans. Conclusions: ABC allowed reproducible BH, and enabled better delineation of tumor and normal structures, as well as reduction in PTV, V20, and spinal cord dose.

Original languageEnglish (US)
Pages (from-to)864-874
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Volume57
Issue number3
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

Keywords

  • Active Breathing Control
  • CHARTWEL
  • Immobilization
  • Non-small-cell lung cancer
  • Respiratory movement

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint

Dive into the research topics of 'Validation of active breathing control in patients with non-small-cell lung cancer to be treated with CHARTWEL'. Together they form a unique fingerprint.

Cite this