Validation of a retrospective respiratory gating method for small-animal CT scanners

Cristina Chavarrías, Juan José Vaquero, Alejandro Sisniega, Alexia Rodríguez-Ruano, María Luisa Soto-Montenegro, Manuel Desco

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a retrospective respiratory gating algorithm to generate dynamic CT studies. To this end, we compared three different methods of extracting the respiratory signal from the projections of small-animal cone-beam computed tomography (CBCT) scanners. Given a set of frames acquired from a certain axial angle, subtraction of their average image from each individual frame produces a set of difference images. The respiratory signals were extracted by analyzing the shape of the histogram of these difference images: we calculated the first four central and non-central moments. However, only odd-order moments produced the desired breathing signal, as the even-order moments lacked information about the phase. Each of these curves was compared to a reference signal recorded by means of a pneumatic pillow. Given the similar correlation coefficients yielded by all of them, we selected the mean to implement our retrospective protocol. Respiratory phase bins were separated, reconstructed independently and included in a dynamic sequence, suitable for cine playback. We validated our method in 5 adult rat studies by comparing profiles drawn across the diaphragm dome, with and without retrospective respiratory gating. Results showed a sharper transition in the gated reconstruction, with an average slope improvement of 60.7%.

Original languageEnglish (US)
Title of host publication2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages4303-4305
Number of pages3
DOIs
StatePublished - Dec 1 2008
Externally publishedYes
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Chavarrías, C., Vaquero, J. J., Sisniega, A., Rodríguez-Ruano, A., Soto-Montenegro, M. L., & Desco, M. (2008). Validation of a retrospective respiratory gating method for small-animal CT scanners. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 (pp. 4303-4305). [4774235] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774235