Validation of a clinical algorithm to identify neonates with severe illness during routine household visits in rural Bangladesh

Gary L. Darmstadt, Abdullah H. Baqui, Yoonjoung Choi, Sanwarul Bari, Syed M. Rahman, Ishtiaq Mannan, A. S.M.Nawshad Uddin Ahmed, Samir K. Saha, Habibur Rahman Seraji, Radwanur Rahman, Peter J. Winch, Stephanie Chang, Nazma Begum, Robert E. Black, Mathuram Santosham, Shams El Arifeen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To validate a clinical algorithm for community health workers (CHWs) during routine household surveillance for neonatal illness in rural Bangladesh. Methods: Surveillance was conducted in the intervention arm of a trial of newborn interventions. CHWs assessed 7587 neonates on postnatal days 0, 2, 5 and 8 and identified neonates with very severe disease (VSD) using an 11-sign algorithm. A nested prospective study was conducted to validate the algorithm (n=395). Physicians evaluated neonates to determine whether newborns with VSD needed referral. The authors calculated algorithm sensitivity and specificity in identifying (1) neonates needing referral and (2) mortality during the first 10 days of life. Results: The 11-sign algorithm had sensitivity of 50.0% (95% CI 24.7% to 75.3%) and specificity of 98.4% (96.6% to 99.4%) for identifying neonates needing referral-level care. A simplified 6-sign algorithm had sensitivity of 81.3% (54.4% to 96.0%) and specificity of 96.0% (93.6% to 97.8%) for identifying referral need and sensitivity of 58.0% (45.5% to 69.8%) and specificity of 93.2% (92.5% to 93.7%) for screening mortality. Compared to our 6-sign algorithm, the Young Infant Study 7-sign (YIS7) algorithm with minor modifications had similar sensitivity and specificity. Conclusion: Community-based surveillance for neonatal illness by CHWs using a simple 6-sign clinical algorithm is a promising strategy to effectively identify neonates at risk of mortality and needing referral to hospital. The YIS7 algorithm was also validated with high sensitivity and specificity at community level, and is recommended for routine household surveillance for newborn illness. ClinicalTrials.gov no. NCT00198627.

Original languageEnglish (US)
Pages (from-to)1140-1146
Number of pages7
JournalArchives of disease in childhood
Volume96
Issue number12
DOIs
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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