Validation and evaluation of model-based crosstalk compensation method in simultaneous 99mTc stress and 201Tl rest myocardial perfusion SPECT

X. Song, E. C. Frey, W. T. Wang, Y. Du, B. M.W. Tsui

Research output: Contribution to journalArticlepeer-review


Simultaneous acquisition of 99mTc stress and 201Tl rest myocardial perfusion SPECT has several potential advantages, but the image quality is degraded by crosstalk between the Tc and Tl data. We have previously developed a crosstalk model that includes estimates of the downscatter and Pb X-ray for use in crosstalk compensation. In this work, we validated the model by comparing the crosstalk from 99mTc to the Tl window calculated using a combination of the SimSET-MCNP Monte Carlo simulation codes. We also evaluated the model-based crosstalk compensation method using both simulated data from the 3-D MCAT phantom and experimental data from a physical phantom with a myocardial defect. In these studies, the Tl distributions were reconstructed from crosstalk contaminated data without crosstalk compensation, with compensation using the model-based crosstalk estimate, and with compensation using the known true crosstalk, and were compared with the Tl distribution reconstructed from uncontaminated Tl data. Results show that the model gave good estimates of both the downscatter photons and Pb X-rays in the simultaneous dual-isotopes myocardial perfusion SPECT. The model-based compensation method provided image quality that was significantly improved as compared to no compensation and was very close to that from the separate acquisition.

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalIEEE Transactions on Nuclear Science
Issue number1 I
StatePublished - Feb 2004


  • Crosstalk compensation
  • Dual-isotope
  • Simultaneous acqusition
  • Single photon emission computed tomography (SPECT)

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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