TY - JOUR
T1 - Vaginal spermicides and outcome of pregnancy
T2 - Findings in a large cohort study
AU - Huggins, George
AU - Vessey, Martin
AU - Flavel, Rosemary
AU - Yeates, David
AU - McPherson, Klim
N1 - Funding Information:
We would like to thank Claire Henry, Patricia Brown, and the research assistants, doctors and nurses in the participating clinics for their enthusiastic and loyal support. We are also grateful to the Medical Research Council for financial support.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1982/3
Y1 - 1982/3
N2 - By the end of 1980, 5729 singleton planned pregnancies, 1552 singleton unplanned pregnancies, and 81 multiple pregnancies had been observed among the 17032 participants in the Oxford-Family Planning Association contraceptive study. The outcome of these pregnancies was investigated in relation to the use of vaginal spermicides. There was some suggestion that spermicide use might have a small adverse effect on the risk of congenital malformations, especially among infants conceived as a result of contraceptive failure. There was not, however, any evidence of any other adverse effect of spermicide use. In particular, the results provide strong evidence against the hypothesis that spermicide use has any appreciable effect on the risk of spontaneous abortion.
AB - By the end of 1980, 5729 singleton planned pregnancies, 1552 singleton unplanned pregnancies, and 81 multiple pregnancies had been observed among the 17032 participants in the Oxford-Family Planning Association contraceptive study. The outcome of these pregnancies was investigated in relation to the use of vaginal spermicides. There was some suggestion that spermicide use might have a small adverse effect on the risk of congenital malformations, especially among infants conceived as a result of contraceptive failure. There was not, however, any evidence of any other adverse effect of spermicide use. In particular, the results provide strong evidence against the hypothesis that spermicide use has any appreciable effect on the risk of spontaneous abortion.
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U2 - 10.1016/0010-7824(82)90045-2
DO - 10.1016/0010-7824(82)90045-2
M3 - Article
C2 - 7075194
AN - SCOPUS:0020057505
SN - 0010-7824
VL - 25
SP - 219
EP - 230
JO - Contraception
JF - Contraception
IS - 3
ER -