Vaginal Microbiota Transplantation: The Next Frontier

Kevin DeLong, Fareeha Zulfiqar, Diane E. Hoffmann, Anita J. Tarzian, Laura M. Ensign

Research output: Contribution to journalArticle

Abstract

The success of fecal microbiota transplantation (FMT) as a treatment for Clostrioides difficile infection (CDI) has stirred excitement about the potential for microbiota transplantation as a therapy for a wide range of diseases and conditions. In this article, we discuss vaginal microbiota transplantation (VMT) as “the next frontier” in microbiota transplantation and identify the medical, regulatory, and ethical challenges related to this nascent field. We further discuss what we anticipate will be the first context for testing VMT in clinical trials, prevention of the recurrence of a condition referred to as bacterial vaginosis (BV). We also compare clinical aspects of VMT with FMT and comment on how VMT may be similar to or different from FMT in ways that may affect research design and regulatory decisions.

Original languageEnglish (US)
Pages (from-to)555-567
Number of pages13
JournalJournal of Law, Medicine and Ethics
Volume47
Issue number4
DOIs
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • Issues, ethics and legal aspects
  • Health Policy

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