Vaginal flora morphotypic profiles and assessment of bacterial vaginosis in women at risk for HIV infection

Beth C. Tohill, Charles M. Heilig, Robert S. Klein, Anne Rompalo, Susan Cu-Uvin, William Brown, Ann Duerr

Research output: Contribution to journalArticlepeer-review

Abstract

Specific morphotypic profiles of normal and abnormal vaginal flora, including bacterial vaginosis (BV), were characterized. A prospective study of 350 women yielded concurrent Gram-stain data and clinical assessment (n = 3455 visits). Microbiological profiles were constructed by Gram stain. Eight profile definitions were based on dichotomizing the levels of Lactobacillus, Gardnerella, and curved, Gram-negative bacillus (Mobiluncus) morphotypes. Of these, two were rare, and the other six demonstrated a graded association with the clinical components of BV. The proposed profiles from the Gram stain reflect the morphotypic categories describing vaginal flora that may enable clearer elucidation of gynecologic and obstetric outcomes in various populations.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalInfectious Disease in Obstetrics and Gynecology
Volume12
Issue number3-4
DOIs
StatePublished - Sep 2004

Keywords

  • Bacterial Vaginosis
  • Gardnerella Vaginalis
  • Genital Infections
  • Gram Stain
  • Lactobacillus
  • Mobiluncus

ASJC Scopus subject areas

  • Dermatology
  • Obstetrics and Gynecology
  • Infectious Diseases

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