Vagal responsiveness to gavage feeding as an index of preterm status

Janet Ann DiPietro, Stephen W. Porges

Research output: Contribution to journalArticle

Abstract

Vagal responsivity to orogastric stimulation is necessary for gastrointestinal function and may reflect autonomic regulation. Our study evaluated vagal responsivity during gavage feeding as an index of preterm clinical status. Vagal and behavioral responsivity of 26 preterm infants during gavage feeding was measured. Vagal tone was quantified with a noninvasive measure (vagal tone index) developed by Porges (Porges SW: U.S. patent 4 510 944,1985), which extracts a valid measure of cardiac vagal tone from the ECG. The study investigated whether vagal tone changed during gavage feeding and whether individual differences in the vagal tone response pattern were related to clinical outcome. Infants who demonstrated an increase in vagal tone during feeding and a decrease after feeding had significantly shorter hospitalizations. This effect was independent of weight gain trajectories. Baseline levels of vagal tone were positively associated with subsequent weight gain. Traditional risk measures did not predict length of hospitalization independently of gestational age. This study represents the first documentation that small changes in cardiac vagal tone during gavage feeding, previously imperceptible to clinicians and researchers, may be quantitatively extracted from the ECG and provide an important index of clinical status.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalPediatric Research
Volume29
Issue number3
StatePublished - 1991

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Weight Gain
Electrocardiography
Hospitalization
Premature Infants
Individuality
Documentation
Gestational Age
Research Personnel

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vagal responsiveness to gavage feeding as an index of preterm status. / DiPietro, Janet Ann; Porges, Stephen W.

In: Pediatric Research, Vol. 29, No. 3, 1991, p. 231-236.

Research output: Contribution to journalArticle

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