Vagal afferent is involved in short-pulse gastric electrical stimulation in rats

Jinsong Liu, Xian Qiao, Jiande Chen

Research output: Contribution to journalArticle

Abstract

This study investigated the effect of gastric electrical stimulation (GES) on vagal activity and its possible vagal afferent-mediated mechanisms. Sixty rats implanted with gastric serosal electrodes were divided into six groups (control, vehicle, local capsaicin, perivagal capsaicin, systemic capsaicin, and vagotomy). GES with six sets of parameters was performed in the control group and GES with one set of effective parameters was performed in the other five groups. Spectral analysis of heart rate variability was used to assess vagal activity. Regular gastric slow waves were recorded in the control rats with a frequency of 4.8 cycles/min. Vagotomy significantly reduced the frequency of the gastric slow wave but did not induce dysrhythmia. Capsaicin did not alter the gastric slow wave. Short-pulse (300-μsec) GES significantly increased vagal activity at a frequency four times the intrinsic slow-wave frequency. Stimulation at a lower frequency or with a long pulse (300 msec) had no effect on vagal activity. Vagotomy or capsaicin administered perivagally, systemically, or locally abolished the effect of GES on the vagal activity. GES with short but not long pulses is capable of altering vagal activity. This effect is mediated by capsaicin-sensitive vagal afferent fibers.

Original languageEnglish (US)
Pages (from-to)729-737
Number of pages9
JournalDigestive Diseases and Sciences
Volume49
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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Electric Stimulation
Stomach
Capsaicin
Vagotomy
Control Groups
Electrodes
Heart Rate

Keywords

  • afferent
  • gastric electrical stimulation
  • pathway
  • vagal activity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Vagal afferent is involved in short-pulse gastric electrical stimulation in rats. / Liu, Jinsong; Qiao, Xian; Chen, Jiande.

In: Digestive Diseases and Sciences, Vol. 49, No. 5, 05.2004, p. 729-737.

Research output: Contribution to journalArticle

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