Vaccine failures in patients properly vaccinated with 13-valent pneumococcal conjugate vaccine in Catalonia, a region with low vaccination coverage

Fernando Moraga-Llop, Juan Jose Garcia-Garcia, Alvaro Díaz-Conradi, Pilar Ciruela, Johanna Martínez-Osorio, Sebastià González-Peris, Sergi Hernández, Mariona Fernández De Sevilla, Sonia Uriona, Conchita Izquierdo, Laura Selva, Magda Campins, Gemma Codina, B. Joan, Cristina Esteva, Àngela Domínguez, Carmen Muñoz-Almagro

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccine failures occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in 3 pediatric hospitals in Barcelona (2012-2013) are described. PCV13 vaccine failure was defined as the occurrence of an invasive pneumococcal infection in children properly vaccinated by PCV13. Among 84 patients with invasive pneumococcal infection, 32 had received at least one dose of PCV13. Seventeen of them had invasive pneumococcal infection produced by a PCV13 serotype. Among those, 9 patients were considered to have a PCV13 vaccine failure. Serotype 3 was isolated in 6 patients, serotype 19A in 2 and serotype 6B in 1.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalPediatric Infectious Disease Journal
Volume35
Issue number4
DOIs
StatePublished - Mar 4 2016

Keywords

  • Conjugate pneumococcal vaccine
  • Pneumococcal invasive disease
  • Streptococcus pneumoniae
  • Vaccine failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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