Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015

Khuzwayo C. Jere, Naor Bar-Zeev, Adams Chande, Aisleen Bennett, Louisa Pollock, Pedro F. Sanchez-Lopez, Osamu Nakagomi, Jacqueline E. Tate, Umesh D. Parashar, Robert S. Heyderman, Neil French, Miren Iturriza-Gomara, Nigel A. Cunliffe

Research output: Contribution to journalArticle

Abstract

Atypical DS-1-like G1P[8] rotaviruses emerged in 2013 in Malawi after rotavirus vaccine introduction. Vaccine effectiveness among infants hospitalized with acute DS-1-like G1P[8] rotavirus gastroenteritis was 85.6% (95% CI 34.4%-96.8%). These findings suggest that vaccine provides protection against these strains despite their emergence coinciding with vaccine introduction.

Original languageEnglish (US)
Pages (from-to)1734-1737
Number of pages4
JournalEmerging infectious diseases
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2019

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Malawi
Rotavirus
Gastroenteritis
Vaccines
Rotavirus Vaccines

Keywords

  • genome constellation
  • genotyping
  • infants
  • Malawi
  • rotavirus
  • vaccine effectiveness
  • vaccines
  • viruses
  • whole-genome sequencing

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015. / Jere, Khuzwayo C.; Bar-Zeev, Naor; Chande, Adams; Bennett, Aisleen; Pollock, Louisa; Sanchez-Lopez, Pedro F.; Nakagomi, Osamu; Tate, Jacqueline E.; Parashar, Umesh D.; Heyderman, Robert S.; French, Neil; Iturriza-Gomara, Miren; Cunliffe, Nigel A.

In: Emerging infectious diseases, Vol. 25, No. 9, 01.09.2019, p. 1734-1737.

Research output: Contribution to journalArticle

Jere, KC, Bar-Zeev, N, Chande, A, Bennett, A, Pollock, L, Sanchez-Lopez, PF, Nakagomi, O, Tate, JE, Parashar, UD, Heyderman, RS, French, N, Iturriza-Gomara, M & Cunliffe, NA 2019, 'Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015', Emerging infectious diseases, vol. 25, no. 9, pp. 1734-1737. https://doi.org/10.3201/eid2509.190258
Jere, Khuzwayo C. ; Bar-Zeev, Naor ; Chande, Adams ; Bennett, Aisleen ; Pollock, Louisa ; Sanchez-Lopez, Pedro F. ; Nakagomi, Osamu ; Tate, Jacqueline E. ; Parashar, Umesh D. ; Heyderman, Robert S. ; French, Neil ; Iturriza-Gomara, Miren ; Cunliffe, Nigel A. / Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015. In: Emerging infectious diseases. 2019 ; Vol. 25, No. 9. pp. 1734-1737.
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