TY - JOUR
T1 - Vaccination serology status and cardiovascular mortality
T2 - Insight from NHANES III and continuous NHANES
AU - Chothani, Ankit
AU - Shah, Neeraj
AU - Patel, Nileshkumar J.
AU - Deshmukh, Abhishek
AU - Singh, Vikas
AU - Patel, Nilay
AU - Panaich, Sidakpal S.
AU - Arora, Shilpkumar
AU - Patel, Achint
AU - Savani, Chirag
AU - Thakkar, Badal
AU - Bhatt, Parth
AU - Cohen, Mauricio G.
AU - Grines, Cindy
AU - Forrest, John K.
AU - Badheka, Apurva O.
N1 - Publisher Copyright:
© 2015 Informa UK Ltd.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective. Prior studies have described a negative relationship between influenza vaccination and recurrence of cardiovascular (CV) events. However, due to lack of any prior studies, we evaluated and attempted to define the relationship between non-influenza vaccines and CV mortality. Methods: We used the National Health and Nutrition Examination Survey III (NHANES III-1988– 1994, n = 19,215) and Continuous NHANES (1999–2004, n > 17,000), which includes oral surveys and general examination. It was designed to assess the demographic, socioeconomic, dietary, and overall health status of a nationally representative sample in non-institutionalized patients from all 50 states in the USA. Cox proportional hazard regression modeling was used to calculate the hazard ratio of CV mortality, and multivariate models were built for the individual seropositive vaccination titers as well as after creating a combined vaccination variable. Results. A total of >35,000 subjects (>18 years old) have been identified for analysis. Multivariate analysis from NHANES III and continuous NHANES did not show any influence of individual seroprotective titers of routine vaccinations on CV mortality. The combined effect of vaccination in NHANES III data did not show any protective effect of three or more positive vaccination titers (odds ratio = 0.94, p = 0.6) or all four positive vaccination titers (odds ratio = 0.93, p = 0.6) with two or less positive vaccination titers as the referent group. Conclusion. Effect on non-influenza vaccinations in preventing CV mortality seems to be unclear.
AB - Objective. Prior studies have described a negative relationship between influenza vaccination and recurrence of cardiovascular (CV) events. However, due to lack of any prior studies, we evaluated and attempted to define the relationship between non-influenza vaccines and CV mortality. Methods: We used the National Health and Nutrition Examination Survey III (NHANES III-1988– 1994, n = 19,215) and Continuous NHANES (1999–2004, n > 17,000), which includes oral surveys and general examination. It was designed to assess the demographic, socioeconomic, dietary, and overall health status of a nationally representative sample in non-institutionalized patients from all 50 states in the USA. Cox proportional hazard regression modeling was used to calculate the hazard ratio of CV mortality, and multivariate models were built for the individual seropositive vaccination titers as well as after creating a combined vaccination variable. Results. A total of >35,000 subjects (>18 years old) have been identified for analysis. Multivariate analysis from NHANES III and continuous NHANES did not show any influence of individual seroprotective titers of routine vaccinations on CV mortality. The combined effect of vaccination in NHANES III data did not show any protective effect of three or more positive vaccination titers (odds ratio = 0.94, p = 0.6) or all four positive vaccination titers (odds ratio = 0.93, p = 0.6) with two or less positive vaccination titers as the referent group. Conclusion. Effect on non-influenza vaccinations in preventing CV mortality seems to be unclear.
KW - Cardiovascular mortality
KW - Hospitalization
KW - Mortality
KW - Vaccination
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U2 - 10.1080/00325481.2015.1064300
DO - 10.1080/00325481.2015.1064300
M3 - Article
C2 - 26174358
AN - SCOPUS:84944175620
SN - 0032-5481
VL - 127
SP - 561
EP - 564
JO - Postgraduate medicine
JF - Postgraduate medicine
IS - 6
ER -