Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation

Cal S. Matsumoto, Stuart S. Kaufman, Raffaele Girlanda, Cheryl M. Little, Yuliya Rekhtman, Vandad Raofi, Jacqueline Laurin, Kirti Shetty, Erin M. Fennelly, Lynt B. Johnson, Thomas M. Fishbein

Research output: Contribution to journalArticle

Abstract

BACKGROUND.: Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal ischemia. Outcomes of recipients who receive intestine grafts that have suffered CPR are unknown. We sought to analyze our clinical experience in using intestinal grafts from donors who suffered cardiopulmonary arrest and resuscitation and to evaluate the outcome of recipients of organs coming from resuscitated donors when compared with recipients of nonresuscitated donors. METHODS.: We retrospectively analyzed the donor and recipient charts of all of our intestinal transplants with regard to the performance of donor CPR. RESULTS.: Sixty-seven intestinal transplants were performed in 65 patients from November 2003 to December 2007. Twelve donors (18%) were identified as having suffered cardiac arrest and subsequent CPR. Mean duration of CPR was 19.3±12.7 min. Terminal laboratory profiles of CPR donors and non-CPR donors were similar. Of the 12 resuscitated grafts, two were used for multivisceral, one for a modified multivisceral, seven for liver-intestine, and two for isolated intestinal transplant. There were no significant differences in outcome parameters such as operative time, blood use, ventilation days, length of stay, time to enteral independence, rejection, enteric bacteremia, and survival between the 12 resuscitated grafts and the 55 nonresuscitated grafts. CONCLUSION.: A donor history of cardiac arrest should not automatically exclude the use of the intestine graft for transplantation.

Original languageEnglish (US)
Pages (from-to)941-946
Number of pages6
JournalTransplantation
Volume86
Issue number7
DOIs
StatePublished - Oct 15 2008
Externally publishedYes

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Cardiopulmonary Resuscitation
Heart Arrest
Transplantation
Tissue Donors
Transplants
Intestines
Cerebrovascular Circulation
Viscera
Operative Time
Bacteremia
Vasoconstriction
Resuscitation
Small Intestine
Ventilation
Length of Stay
Ischemia

Keywords

  • Intestinal transplant
  • Marginal donor
  • Organ procurement

ASJC Scopus subject areas

  • Transplantation

Cite this

Matsumoto, C. S., Kaufman, S. S., Girlanda, R., Little, C. M., Rekhtman, Y., Raofi, V., ... Fishbein, T. M. (2008). Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation. Transplantation, 86(7), 941-946. https://doi.org/10.1097/TP.0b013e3181852f9a

Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation. / Matsumoto, Cal S.; Kaufman, Stuart S.; Girlanda, Raffaele; Little, Cheryl M.; Rekhtman, Yuliya; Raofi, Vandad; Laurin, Jacqueline; Shetty, Kirti; Fennelly, Erin M.; Johnson, Lynt B.; Fishbein, Thomas M.

In: Transplantation, Vol. 86, No. 7, 15.10.2008, p. 941-946.

Research output: Contribution to journalArticle

Matsumoto, CS, Kaufman, SS, Girlanda, R, Little, CM, Rekhtman, Y, Raofi, V, Laurin, J, Shetty, K, Fennelly, EM, Johnson, LB & Fishbein, TM 2008, 'Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation', Transplantation, vol. 86, no. 7, pp. 941-946. https://doi.org/10.1097/TP.0b013e3181852f9a
Matsumoto, Cal S. ; Kaufman, Stuart S. ; Girlanda, Raffaele ; Little, Cheryl M. ; Rekhtman, Yuliya ; Raofi, Vandad ; Laurin, Jacqueline ; Shetty, Kirti ; Fennelly, Erin M. ; Johnson, Lynt B. ; Fishbein, Thomas M. / Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation. In: Transplantation. 2008 ; Vol. 86, No. 7. pp. 941-946.
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abstract = "BACKGROUND.: Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal ischemia. Outcomes of recipients who receive intestine grafts that have suffered CPR are unknown. We sought to analyze our clinical experience in using intestinal grafts from donors who suffered cardiopulmonary arrest and resuscitation and to evaluate the outcome of recipients of organs coming from resuscitated donors when compared with recipients of nonresuscitated donors. METHODS.: We retrospectively analyzed the donor and recipient charts of all of our intestinal transplants with regard to the performance of donor CPR. RESULTS.: Sixty-seven intestinal transplants were performed in 65 patients from November 2003 to December 2007. Twelve donors (18{\%}) were identified as having suffered cardiac arrest and subsequent CPR. Mean duration of CPR was 19.3±12.7 min. Terminal laboratory profiles of CPR donors and non-CPR donors were similar. Of the 12 resuscitated grafts, two were used for multivisceral, one for a modified multivisceral, seven for liver-intestine, and two for isolated intestinal transplant. There were no significant differences in outcome parameters such as operative time, blood use, ventilation days, length of stay, time to enteral independence, rejection, enteric bacteremia, and survival between the 12 resuscitated grafts and the 55 nonresuscitated grafts. CONCLUSION.: A donor history of cardiac arrest should not automatically exclude the use of the intestine graft for transplantation.",
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T1 - Utilization of donors who have suffered cardiopulmonary arrest and resuscitation in intestinal transplantation

AU - Matsumoto, Cal S.

AU - Kaufman, Stuart S.

AU - Girlanda, Raffaele

AU - Little, Cheryl M.

AU - Rekhtman, Yuliya

AU - Raofi, Vandad

AU - Laurin, Jacqueline

AU - Shetty, Kirti

AU - Fennelly, Erin M.

AU - Johnson, Lynt B.

AU - Fishbein, Thomas M.

PY - 2008/10/15

Y1 - 2008/10/15

N2 - BACKGROUND.: Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal ischemia. Outcomes of recipients who receive intestine grafts that have suffered CPR are unknown. We sought to analyze our clinical experience in using intestinal grafts from donors who suffered cardiopulmonary arrest and resuscitation and to evaluate the outcome of recipients of organs coming from resuscitated donors when compared with recipients of nonresuscitated donors. METHODS.: We retrospectively analyzed the donor and recipient charts of all of our intestinal transplants with regard to the performance of donor CPR. RESULTS.: Sixty-seven intestinal transplants were performed in 65 patients from November 2003 to December 2007. Twelve donors (18%) were identified as having suffered cardiac arrest and subsequent CPR. Mean duration of CPR was 19.3±12.7 min. Terminal laboratory profiles of CPR donors and non-CPR donors were similar. Of the 12 resuscitated grafts, two were used for multivisceral, one for a modified multivisceral, seven for liver-intestine, and two for isolated intestinal transplant. There were no significant differences in outcome parameters such as operative time, blood use, ventilation days, length of stay, time to enteral independence, rejection, enteric bacteremia, and survival between the 12 resuscitated grafts and the 55 nonresuscitated grafts. CONCLUSION.: A donor history of cardiac arrest should not automatically exclude the use of the intestine graft for transplantation.

AB - BACKGROUND.: Cardiopulmonary resuscitation (CPR) of a person destined to become an organ donor has been associated with overall poor donor quality, especially for the intestinal donor, as splanchnic vasoconstriction that is intended to preserve coronary and cerebral blood flow may result in clinically relevant intestinal ischemia. Outcomes of recipients who receive intestine grafts that have suffered CPR are unknown. We sought to analyze our clinical experience in using intestinal grafts from donors who suffered cardiopulmonary arrest and resuscitation and to evaluate the outcome of recipients of organs coming from resuscitated donors when compared with recipients of nonresuscitated donors. METHODS.: We retrospectively analyzed the donor and recipient charts of all of our intestinal transplants with regard to the performance of donor CPR. RESULTS.: Sixty-seven intestinal transplants were performed in 65 patients from November 2003 to December 2007. Twelve donors (18%) were identified as having suffered cardiac arrest and subsequent CPR. Mean duration of CPR was 19.3±12.7 min. Terminal laboratory profiles of CPR donors and non-CPR donors were similar. Of the 12 resuscitated grafts, two were used for multivisceral, one for a modified multivisceral, seven for liver-intestine, and two for isolated intestinal transplant. There were no significant differences in outcome parameters such as operative time, blood use, ventilation days, length of stay, time to enteral independence, rejection, enteric bacteremia, and survival between the 12 resuscitated grafts and the 55 nonresuscitated grafts. CONCLUSION.: A donor history of cardiac arrest should not automatically exclude the use of the intestine graft for transplantation.

KW - Intestinal transplant

KW - Marginal donor

KW - Organ procurement

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