Utility of Various Radionuclide Techniques for Distinguishing Ischemic From Nonischemic Dilated Cardiomyopathy

D. Brent Glamann, Richard A. Lange, James R. Corbett, L. David Hillis

Research output: Contribution to journalArticle

Abstract

Background.—Clinically, ischemic and nonischemic (idiopathic) dilated cardiomyopathy may be difficult to distinguish. Radionuclide ventriculography and exercise testing with thallium-201 scintigraphy are often used in an attempt to differentiate them noninvasively. With these techniques, the presence of (1) left ventricular (LV) regional asynergy, (2) depressed LV systolic function with normal right ventricular function, and/or (3) thallium-201 perfusion abnormalities traditionally has been regarded as evidence of ischemic heart disease. We assessed the incidence with which these abnormalities occur in patients with nonischemic-dilated cardiomyopathy. Methods.—Seventy-six patients (45 men, 31 women, aged 18 to 75 years) with invasively proven nonischemicdilated cardiomyopathy underwent radionuclide ventriculography (n = 75) and provocative thallium-201 perfusion imaging (n = 17). Results.—Regional LV wall motion abnormalities were noted in 48% of patients, and 54% had LV systolic dysfunction without concomitant right ventricular dysfunction. Reversible and/or fixed exercise-induced thallium-201 perfusion abnormalities occurred in 94% of the patients studied. Conclusions.—Radionuclide ventriculography and exercise testing with thallium perfusion imaging cannot be used reliably to differentiate ischemic from nonischemic dilated cardiomyopathy, since many patients with the latter have radionuclide evidence of LV segmental wall motion abnormalities, selective LV systolic dysfunction, and segmental perfusion abnormalities.

Original languageEnglish (US)
Pages (from-to)769-772
Number of pages4
JournalArchives of Internal Medicine
Volume152
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

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Thallium
Dilated Cardiomyopathy
Radioisotopes
Radionuclide Ventriculography
Perfusion Imaging
Perfusion
Left Ventricular Dysfunction
Exercise
Right Ventricular Dysfunction
Right Ventricular Function
Cardiomyopathies
Left Ventricular Function
Radionuclide Imaging
Myocardial Ischemia
Incidence

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Utility of Various Radionuclide Techniques for Distinguishing Ischemic From Nonischemic Dilated Cardiomyopathy. / Glamann, D. Brent; Lange, Richard A.; Corbett, James R.; Hillis, L. David.

In: Archives of Internal Medicine, Vol. 152, No. 4, 1992, p. 769-772.

Research output: Contribution to journalArticle

Glamann, D. Brent ; Lange, Richard A. ; Corbett, James R. ; Hillis, L. David. / Utility of Various Radionuclide Techniques for Distinguishing Ischemic From Nonischemic Dilated Cardiomyopathy. In: Archives of Internal Medicine. 1992 ; Vol. 152, No. 4. pp. 769-772.
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