Utility of uroplakin II expression as a marker of urothelial carcinoma

Wei Tian, Gunes Guner, Hiroshi Miyamoto, Ashley M Cimino-Mathews, Nilda Gonzalez-Roibon, Pedram Argani, Xuan Li, Rajni Sharma, Andrea P. Subhawong, Katayoon Rezaei, Trinity Bivalacqua, Jonathan Ira Epstein, Justin A. Bishop, George J. Netto

Research output: Contribution to journalArticle


Uroplakins are markers of terminally differentiated urothelium. Uroplakin II (UPII) is a newly described sensitive marker for urothelial carcinoma (UC). The expression profile of UPII in different types of UC and its utility in the diagnostic setting are needed. We evaluated UPII expression in bladder tissue microarrays, including urothelial neoplasm of low malignant potential (n = 8), low-grade papillary UC (n = 72), noninvasive high-grade papillary UC (n = 77), UC in situ (n = 27), and invasive high-grade UC (INVUC) (n = 122). UPII expression in 52 breast carcinomas and 38 high-grade prostate adenocarcinomas was also assessed. UPII expression was compared with GATA binding protein 3 (GATA3) and estrogen receptor for its role in facilitating the differential diagnosis of the above 3 types of malignancy. UPII labeling was seen in 83.0% of UC overall, including 95.7% of noninvasive UC and 65.6% of INVUC. UPII labeling was not found in any breast and prostate carcinomas. In comparison, GATA3 labeling was seen in 91.6% of all UCs, including 96.4% of noninvasive UCs and 85.1% of INVUC, with stronger intensity and extent compared with UPII (P

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalHuman Pathology
Issue number1
StatePublished - Jan 1 2015



  • Bladder cancer
  • Breast carcinoma
  • GATA3
  • Immunohistochemistry
  • Uroplakin II

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Tian, W., Guner, G., Miyamoto, H., Cimino-Mathews, A. M., Gonzalez-Roibon, N., Argani, P., Li, X., Sharma, R., Subhawong, A. P., Rezaei, K., Bivalacqua, T., Epstein, J. I., Bishop, J. A., & Netto, G. J. (2015). Utility of uroplakin II expression as a marker of urothelial carcinoma. Human Pathology, 46(1), 58-64. https://doi.org/10.1016/j.humpath.2014.09.007