Utility of tuberculin and anergy skin testing in predicting tuberculosis infection in human immunodeficiency virus-infected persons in Thailand

H. Yanai, W. Uthaivoravit, T. D. Mastro, K. Limpakarnjanarat, P. Sawanpanyalert, R. H. Morrow, P. Nieburg

Research output: Contribution to journalArticle

Abstract

SETTING: Chiang Rai, the northernmost province of Thailand, where extensive human immunodeficiency virus (HIV) transmission has resulted in a rapid increase in tuberculosis. OBJECTIVE: To assess the utility of tuberculin and anergy skin testing to identify latent Mycobacterium tuberculosis infection in HIV-infected persons. DESIGN: A cross-sectional study and analysis were conducted to examine reactivity to tuberculin and two control antigens (mumps and candida) in HIV-negative and HIV-positive blood donors and female sex workers. RESULTS: HIV-positive persons had markedly decreased tuberculin reactivity; 14%, 19%, and 40% had an induration of ≥10 mm, ≥ 5 mm, ≥ 2 mm, respectively, while 51% of 525 HIV-negative persons had an induration of ≥ 10 mm (P <0.001). Mumps and candida positivity (reactions of ≥ 3 mm) were found in 94% and 78% of HIV-negative persons compared with 72% and 61% of HIV-positive persons, respectively (P <0.001). Although HIV-positive persons had markedly less tuberculin reactivity even at higher CD4+ cell counts (>400 cells/μL), reactivity to mumps and candida was present in more than half of HIV-positive persons with low CD4+ cell counts (≤200 cells/μL). Reaction to control antigens did not predict tuberculin reactivity. CONCLUSION: In this setting, tuberculin and anergy skin testing have a low predictive value in detecting M. tuberculosis infection in HIV-infected persons, and therefore such testing has a limited role in identifying HIV-infected persons who may benefit from tuberculosis preventive therapy programs.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume1
Issue number5
StatePublished - 1997

Fingerprint

Tuberculin
Thailand
Tuberculosis
HIV
Skin
Infection
Mumps
Mycobacterium Infections
Candida
Mycobacterium tuberculosis
Cross-Sectional Studies
Preventive Health Services
Latent Tuberculosis
Antigens
Sex Workers
CD4 Lymphocyte Count
Blood Donors

Keywords

  • AIDS
  • Asia
  • HIV
  • Skin testing
  • Thailand
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Yanai, H., Uthaivoravit, W., Mastro, T. D., Limpakarnjanarat, K., Sawanpanyalert, P., Morrow, R. H., & Nieburg, P. (1997). Utility of tuberculin and anergy skin testing in predicting tuberculosis infection in human immunodeficiency virus-infected persons in Thailand. International Journal of Tuberculosis and Lung Disease, 1(5), 427-434.

Utility of tuberculin and anergy skin testing in predicting tuberculosis infection in human immunodeficiency virus-infected persons in Thailand. / Yanai, H.; Uthaivoravit, W.; Mastro, T. D.; Limpakarnjanarat, K.; Sawanpanyalert, P.; Morrow, R. H.; Nieburg, P.

In: International Journal of Tuberculosis and Lung Disease, Vol. 1, No. 5, 1997, p. 427-434.

Research output: Contribution to journalArticle

Yanai, H, Uthaivoravit, W, Mastro, TD, Limpakarnjanarat, K, Sawanpanyalert, P, Morrow, RH & Nieburg, P 1997, 'Utility of tuberculin and anergy skin testing in predicting tuberculosis infection in human immunodeficiency virus-infected persons in Thailand', International Journal of Tuberculosis and Lung Disease, vol. 1, no. 5, pp. 427-434.
Yanai, H. ; Uthaivoravit, W. ; Mastro, T. D. ; Limpakarnjanarat, K. ; Sawanpanyalert, P. ; Morrow, R. H. ; Nieburg, P. / Utility of tuberculin and anergy skin testing in predicting tuberculosis infection in human immunodeficiency virus-infected persons in Thailand. In: International Journal of Tuberculosis and Lung Disease. 1997 ; Vol. 1, No. 5. pp. 427-434.
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AU - Uthaivoravit, W.

AU - Mastro, T. D.

AU - Limpakarnjanarat, K.

AU - Sawanpanyalert, P.

AU - Morrow, R. H.

AU - Nieburg, P.

PY - 1997

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N2 - SETTING: Chiang Rai, the northernmost province of Thailand, where extensive human immunodeficiency virus (HIV) transmission has resulted in a rapid increase in tuberculosis. OBJECTIVE: To assess the utility of tuberculin and anergy skin testing to identify latent Mycobacterium tuberculosis infection in HIV-infected persons. DESIGN: A cross-sectional study and analysis were conducted to examine reactivity to tuberculin and two control antigens (mumps and candida) in HIV-negative and HIV-positive blood donors and female sex workers. RESULTS: HIV-positive persons had markedly decreased tuberculin reactivity; 14%, 19%, and 40% had an induration of ≥10 mm, ≥ 5 mm, ≥ 2 mm, respectively, while 51% of 525 HIV-negative persons had an induration of ≥ 10 mm (P <0.001). Mumps and candida positivity (reactions of ≥ 3 mm) were found in 94% and 78% of HIV-negative persons compared with 72% and 61% of HIV-positive persons, respectively (P <0.001). Although HIV-positive persons had markedly less tuberculin reactivity even at higher CD4+ cell counts (>400 cells/μL), reactivity to mumps and candida was present in more than half of HIV-positive persons with low CD4+ cell counts (≤200 cells/μL). Reaction to control antigens did not predict tuberculin reactivity. CONCLUSION: In this setting, tuberculin and anergy skin testing have a low predictive value in detecting M. tuberculosis infection in HIV-infected persons, and therefore such testing has a limited role in identifying HIV-infected persons who may benefit from tuberculosis preventive therapy programs.

AB - SETTING: Chiang Rai, the northernmost province of Thailand, where extensive human immunodeficiency virus (HIV) transmission has resulted in a rapid increase in tuberculosis. OBJECTIVE: To assess the utility of tuberculin and anergy skin testing to identify latent Mycobacterium tuberculosis infection in HIV-infected persons. DESIGN: A cross-sectional study and analysis were conducted to examine reactivity to tuberculin and two control antigens (mumps and candida) in HIV-negative and HIV-positive blood donors and female sex workers. RESULTS: HIV-positive persons had markedly decreased tuberculin reactivity; 14%, 19%, and 40% had an induration of ≥10 mm, ≥ 5 mm, ≥ 2 mm, respectively, while 51% of 525 HIV-negative persons had an induration of ≥ 10 mm (P <0.001). Mumps and candida positivity (reactions of ≥ 3 mm) were found in 94% and 78% of HIV-negative persons compared with 72% and 61% of HIV-positive persons, respectively (P <0.001). Although HIV-positive persons had markedly less tuberculin reactivity even at higher CD4+ cell counts (>400 cells/μL), reactivity to mumps and candida was present in more than half of HIV-positive persons with low CD4+ cell counts (≤200 cells/μL). Reaction to control antigens did not predict tuberculin reactivity. CONCLUSION: In this setting, tuberculin and anergy skin testing have a low predictive value in detecting M. tuberculosis infection in HIV-infected persons, and therefore such testing has a limited role in identifying HIV-infected persons who may benefit from tuberculosis preventive therapy programs.

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