Utility of on-site cytopathology assessment for bronchoscopic evaluation of lung masses and adenopathy

Gregory B. Diette, Peter White, Peter Terry, Mollie Jenckes, Dorothy Rosenthal, Haya R. Rubin

Research output: Contribution to journalArticlepeer-review

Abstract

Study objectives: To determine the extent to which on-site cytopathology assessment improves i diagnostic yield when sampling lung nodules or masses and/or hilar or mediastinal lymphadenopathy by fiberoptic bronchoscopy (FOB). Design: Prospective cohort study. Setting: Two teaching hospitals in Baltimore, MD. Patients: Consecutive adult patients (≥ 18 years) undergoing FOB for evaluation of lung nodules or masses and/or hilar or mediastinal lymphadenopathy. Intervention: Prospective collection of data on patient factors and details of the procedure on standardized report forms. Measurements and results: The primary outcome measure was a new diagnosis obtained by FOB. On-site assessment was used in 81 of 204 cases (40%), and overall diagnostic yield was 62%. Yield was greater when on-site cytopathology assessment was used, in unadjusted analysis (81% vs 50%, p < 0.001) and in a multivariate model (odds ratio, 4.5; 95% confidence interval, 2.1 to 10.0). Other significant predictors of a new diagnosis included older patient age, higher dose of narcotic used during FOB, and shorter procedure time. Conclusions: We conclude that diagnostic yield was greater when on-site cytopathology was used to assist FOB evaluation of intrathoracic adenopathy and/or lung nodules or masses. Increasing the use of on-site cytopathology assessment may improve the quality of FOB services.

Original languageEnglish (US)
Pages (from-to)1186-1190
Number of pages5
JournalCHEST
Volume117
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Cytopathology
  • Fiberoptic bronchoscopy
  • Lung cancer
  • Quality of care

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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